4-(1-(4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)-2-methoxyphenoxy)-2-methylpropan-2-yloxy)-4-oxobutanoic acid

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Chemical Name:4-(1-(4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)-2-methoxyphenoxy)-2-methylpropan-2-yloxy)-4-oxobutanoic acid
CAS No.:1346773-82-7
Molecular Formula:C₂₇H₂₅ClN₂O₇S
Molecular Weight:557.024
Hs Code.:

Synonyms:4-(1-(4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)-2-methoxyphenoxy)-2-methylpropan-2-yloxy)-4-oxobutanoic acid

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Chemical Property of 4-(1-(4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)-2-methoxyphenoxy)-2-methylpropan-2-yloxy)-4-oxobutanoic acid

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Technology Process of 4-(1-(4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)-2-methoxyphenoxy)-2-methylpropan-2-yloxy)-4-oxobutanoic acid

There total 4 articles about 4-(1-(4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)-2-methoxyphenoxy)-2-methylpropan-2-yloxy)-4-oxobutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 108-30-5
succinic acid anhydride

: 1026063-71-7
C₂₃H₂₁ClN₂O₄S

: 1346773-82-7
4-(1-(4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)-2-methoxyphenoxy)-2-methylpropan-2-yloxy)-4-oxobutanoic acid

Guidance literature:: With dmap; In N,N-dimethyl acetamide; at 140 ℃; for 7h;
DOI:10.1021/jm500026w

Reference yield:

: 100200-99-5
potassium 2-methoxy-4-nitrophenolate monohydrate

: 1346773-82-7
4-(1-(4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)-2-methoxyphenoxy)-2-methylpropan-2-yloxy)-4-oxobutanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: sodium dihydrogenphosphate / water; acetonitrile / 3 h / 170 °C / 155149 Torr / Autoclave; Inert atmosphere

2: hydrogen; palladium 10% on activated carbon / ethanol / 6 h / 3102.97 Torr / Inert atmosphere

3: ethanol / 15 h / Reflux; Inert atmosphere

4: dmap / N,N-dimethyl acetamide / 7 h / 140 °C

With dmap; sodium dihydrogenphosphate; palladium 10% on activated carbon; hydrogen; In ethanol; N,N-dimethyl acetamide; water; acetonitrile;
DOI:10.1021/jm500026w

Reference yield:

: 945720-36-5
1-(2-methoxy-4-nitrophenoxy)-2-methylpropan-2-ol

: 1346773-82-7
4-(1-(4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)-2-methoxyphenoxy)-2-methylpropan-2-yloxy)-4-oxobutanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen; palladium 10% on activated carbon / ethanol / 6 h / 3102.97 Torr / Inert atmosphere

2: ethanol / 15 h / Reflux; Inert atmosphere

3: dmap / N,N-dimethyl acetamide / 7 h / 140 °C

With dmap; palladium 10% on activated carbon; hydrogen; In ethanol; N,N-dimethyl acetamide;
DOI:10.1021/jm500026w