5-(2,3,4-trimethoxy-phenyl)-5-oxo-pentanoic acid methyl ester

Base Information

• Chemical Name: 5-(2,3,4-trimethoxy-phenyl)-5-oxo-pentanoic acid methyl ester
• CAS No.: 412012-34-1
• Molecular Formula: C₁₅H₂₀O₆
• Molecular Weight: 296.32
• Mol file: 412012-34-1.mol

Synonyms:5-(2,3,4-trimethoxy-phenyl)-5-oxo-pentanoic acid methyl ester

Chemical Property of 5-(2,3,4-trimethoxy-phenyl)-5-oxo-pentanoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(2,3,4-trimethoxy-phenyl)-5-oxo-pentanoic acid methyl ester

There total 4 articles about 5-(2,3,4-trimethoxy-phenyl)-5-oxo-pentanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

Pentanedioic acid, monomethyl ester (1501-27-5) + 1,2,3-trimethoxybenzene (634-36-6) → 5-(2,3,4-trimethoxy-phenyl)-5-oxo-pentanoic acid methyl ester (412012-34-1)

Guidance literature:

With PPA; Polyphosphoric acid (PPA); at 45 ℃; for 2.5h;

Reference yield:

methanol (67-56-1) + 5-(2,3,4-trimethoxy-phenyl)-5-oxo-pentanoic acid (16093-16-6) + methyl iodide (74-88-4) → 5-(2,3,4-trimethoxy-phenyl)-5-oxo-pentanoic acid methyl ester (412012-34-1)

Guidance literature:

methanol; 5-(2,3,4-trimethoxy-phenyl)-5-oxo-pentanoic acid; With hydrogenchloride; at 20 ℃;

methyl iodide; With potassium carbonate; In acetone; Heating;

DOI:10.1021/ol062666p

Reference yield:

glutaric anhydride, (108-55-4) → 5-(2,3,4-trimethoxy-phenyl)-5-oxo-pentanoic acid methyl ester (412012-34-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: AlCl₃ / nitrobenzene / 48 h / 20 °C

2.1: HCl (gas) / 20 °C

2.2: 2.6 g / K₂CO₃ / acetone / Heating

With hydrogenchloride; aluminium trichloride; In nitrobenzene;

DOI:10.1021/ol062666p

upstream raw materials:

methanol

5-(2,3,4-trimethoxy-phenyl)-5-oxo-pentanoic acid

methyl iodide

glutaric anhydride,

Downstream raw materials:

5-(2,3,4-trimethoxy-phenyl)-5-oxo-pentanoic acid