(R)-2-methyl-2-phenylsuccinic acid

Base Information

Chemical Name:(R)-2-methyl-2-phenylsuccinic acid
CAS No.:106358-84-3
Molecular Formula:C₁₁H₁₀O₃
Molecular Weight:190.199
Hs Code.:

Synonyms:(R)-2-methyl-2-phenylsuccinic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-methyl-2-phenylsuccinic acid

Chemical Property:

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Technology Process of (R)-2-methyl-2-phenylsuccinic acid

There total 11 articles about (R)-2-methyl-2-phenylsuccinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (R)-3-Methyl-3-phenyl-tetrahydro-furan-2,5-diol

: 106358-84-3
(R)-2-methyl-2-phenylsuccinic acid

Guidance literature:: With sulfuric acid; chromic acid; In acetone; at 0 ℃;
DOI:10.1021/ja00238a047

Reference yield:

: 98-86-2
acetophenone

: 106358-84-3
(R)-2-methyl-2-phenylsuccinic acid

Guidance literature:: Multi-step reaction with 8 steps

1: 1) n-BuLi / 2) 20 deg C, 4 h

2: 1) p-TsOH, 2) AcCl / 1) benzene, reflux, 3.5 h, 2) CH₂Cl₂, 0 deg C, 2 h

3: TiCl₄, Pb(OH)2 / acetonitrile; H₂O / 18 h / Ambient temperature

5: NaBH₄

6: toluene; acetic acid / 8 h / 0 °C

7: KOH / methanol / Ambient temperature

8: chromic acid, H₂SO₄ / acetone / 0 °C

With potassium hydroxide; sodium tetrahydroborate; n-butyllithium; lead(II) hydroxide on calcium carbonate; sulfuric acid; titanium tetrachloride; chromic acid; toluene-4-sulfonic acid; acetyl chloride; In methanol; water; acetic acid; acetone; toluene; acetonitrile;
DOI:10.1021/ja00238a047

Reference yield:

: 106358-77-4
(R)-(-)-4-Methyl-4-phenyl-1-p-toluenesulfenylcyclobutene

: 106358-84-3
(R)-2-methyl-2-phenylsuccinic acid

Guidance literature:: Multi-step reaction with 6 steps

1: TiCl₄, Pb(OH)2 / acetonitrile; H₂O / 18 h / Ambient temperature

3: NaBH₄

4: toluene; acetic acid / 8 h / 0 °C

5: KOH / methanol / Ambient temperature

6: chromic acid, H₂SO₄ / acetone / 0 °C

With potassium hydroxide; sodium tetrahydroborate; lead(II) hydroxide on calcium carbonate; sulfuric acid; titanium tetrachloride; chromic acid; In methanol; water; acetic acid; acetone; toluene; acetonitrile;
DOI:10.1021/ja00238a047