N-(3-(3-(6-chloropyrimidin-4-yl)ureido)-2,4-difluorophenyl)-propane-1-sulfonamide

Base Information

Chemical Name:N-(3-(3-(6-chloropyrimidin-4-yl)ureido)-2,4-difluorophenyl)-propane-1-sulfonamide
CAS No.:1269652-13-2
Molecular Formula:C₁₄H₁₄ClF₂N₅O₃S
Molecular Weight:405.813
Hs Code.:

Synonyms:N-(3-(3-(6-chloropyrimidin-4-yl)ureido)-2,4-difluorophenyl)-propane-1-sulfonamide

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Chemical Property of N-(3-(3-(6-chloropyrimidin-4-yl)ureido)-2,4-difluorophenyl)-propane-1-sulfonamide

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Technology Process of N-(3-(3-(6-chloropyrimidin-4-yl)ureido)-2,4-difluorophenyl)-propane-1-sulfonamide

There total 6 articles about N-(3-(3-(6-chloropyrimidin-4-yl)ureido)-2,4-difluorophenyl)-propane-1-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1103234-57-6
N-(3-amino-2,4-difluorophenyl)propane-1-sulfonamide

: 1269652-10-9
phenyl 6-chloropyrimidin-4-ylcarbamate

: 1269652-13-2
N-(3-(3-(6-chloropyrimidin-4-yl)ureido)-2,4-difluorophenyl)-propane-1-sulfonamide

Guidance literature:: In 1,2-dichloro-ethane; at 90 ℃; for 15h;

Reference yield:

: 83141-10-0
2,6-difluoro-3-nitrobenzoic acid

: 1269652-13-2
N-(3-(3-(6-chloropyrimidin-4-yl)ureido)-2,4-difluorophenyl)-propane-1-sulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: methanol / 2 h / Cold water bath

2.1: hydrogen / palladium 10% on activated carbon / ethanol / Inert atmosphere

3.1: triethylamine / dichloromethane / 1 h / 20 °C / Cool water bath

4.1: sodium hydroxide; water / tetrahydrofuran; methanol / 20 °C

5.1: triethylamine; diphenyl phosphoryl azide / tetrahydrofuran / 5 h / 20 - 80 °C

5.2: 15 h / 80 °C

6.1: 1,2-dichloro-ethane / 15 h / 90 °C

With diphenyl phosphoryl azide; water; hydrogen; triethylamine; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; 1,2-dichloro-ethane;

Reference yield:

: 84832-01-9
methyl 2,6-difluoro-3-nitrobenzoate

: 1269652-13-2
N-(3-(3-(6-chloropyrimidin-4-yl)ureido)-2,4-difluorophenyl)-propane-1-sulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol / Inert atmosphere

2.1: triethylamine / dichloromethane / 1 h / 20 °C / Cool water bath

3.1: sodium hydroxide; water / tetrahydrofuran; methanol / 20 °C

4.1: triethylamine; diphenyl phosphoryl azide / tetrahydrofuran / 5 h / 20 - 80 °C

4.2: 15 h / 80 °C

5.1: 1,2-dichloro-ethane / 15 h / 90 °C

With diphenyl phosphoryl azide; water; hydrogen; triethylamine; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; 1,2-dichloro-ethane;