N-(5-((4-(hydroxymethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)methyl)-2,3-dihydro-1H-inden-1-yl)-2-methoxybenzenesulfonamide

Base Information

Chemical Name:N-(5-((4-(hydroxymethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)methyl)-2,3-dihydro-1H-inden-1-yl)-2-methoxybenzenesulfonamide
CAS No.:1199828-95-9
Molecular Formula:C₂₂H₂₂F₃N₃O₄S
Molecular Weight:481.496
Hs Code.:

Synonyms:N-(5-((4-(hydroxymethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)methyl)-2,3-dihydro-1H-inden-1-yl)-2-methoxybenzenesulfonamide

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Chemical Property of N-(5-((4-(hydroxymethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)methyl)-2,3-dihydro-1H-inden-1-yl)-2-methoxybenzenesulfonamide

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Technology Process of N-(5-((4-(hydroxymethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)methyl)-2,3-dihydro-1H-inden-1-yl)-2-methoxybenzenesulfonamide

There total 10 articles about N-(5-((4-(hydroxymethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)methyl)-2,3-dihydro-1H-inden-1-yl)-2-methoxybenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 1199829-06-5
(1-((1-amino-2,3-dihydro-1H-inden-5-yl)methyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)methanol

: 10130-87-7
o-Methoxybenzenesulfonyl chloride

: 1199828-95-9
N-(5-((4-(hydroxymethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)methyl)-2,3-dihydro-1H-inden-1-yl)-2-methoxybenzenesulfonamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 3h;

Reference yield:

: 185122-63-8
5-bromo-2,3-dihydro-1H-inden-1-one oxime

: 1199828-95-9
N-(5-((4-(hydroxymethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)methyl)-2,3-dihydro-1H-inden-1-yl)-2-methoxybenzenesulfonamide

Guidance literature:: Multi-step reaction with 9 steps

1: acetic acid; zinc / ethanol / 72 h / 20 °C

2: potassium carbonate / water; ethyl acetate

3: 1,8-diazabicyclo[5.4.0]undec-7-ene; tri tert-butylphosphoniumtetrafluoroborate; molybdenum hexacarbonyl / methanol; acetonitrile / 0.5 h / 150 °C / Irradiation with microwave

4: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C

5: thionyl chloride / dichloromethane / 2 h / 20 °C

6: potassium carbonate / N,N-dimethyl-formamide / 2 h / 60 °C

7: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

8: hydrogen / palladium(II) hydroxide / ethanol / 0.5 h / 1500.15 Torr

9: triethylamine / dichloromethane / 3 h / 20 °C

With lithium aluminium tetrahydride; thionyl chloride; hydrogen; potassium carbonate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; tri tert-butylphosphoniumtetrafluoroborate; zinc; molybdenum hexacarbonyl; palladium(II) hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 185122-74-1
5-bromo-2,3-dihydro-1H-inden-1-one oxime

: 1199828-95-9
N-(5-((4-(hydroxymethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)methyl)-2,3-dihydro-1H-inden-1-yl)-2-methoxybenzenesulfonamide

Guidance literature:: Multi-step reaction with 8 steps

1: potassium carbonate / water; ethyl acetate

2: 1,8-diazabicyclo[5.4.0]undec-7-ene; tri tert-butylphosphoniumtetrafluoroborate; molybdenum hexacarbonyl / methanol; acetonitrile / 0.5 h / 150 °C / Irradiation with microwave

3: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C

4: thionyl chloride / dichloromethane / 2 h / 20 °C

5: potassium carbonate / N,N-dimethyl-formamide / 2 h / 60 °C

6: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

7: hydrogen / palladium(II) hydroxide / ethanol / 0.5 h / 1500.15 Torr

8: triethylamine / dichloromethane / 3 h / 20 °C

With lithium aluminium tetrahydride; thionyl chloride; hydrogen; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; tri tert-butylphosphoniumtetrafluoroborate; molybdenum hexacarbonyl; palladium(II) hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;