R_p-(-)-menthyl benzylmethylphosphinate

Base Information

• Chemical Name: R_p-(-)-menthyl benzylmethylphosphinate
• CAS No.: 126441-54-1
• Molecular Formula: C₁₈H₂₉O₂P
• Molecular Weight: 308.401
• Mol file: 126441-54-1.mol

Synonyms:R_p-(-)-menthyl benzylmethylphosphinate

Chemical Property of R_p-(-)-menthyl benzylmethylphosphinate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of R_p-(-)-menthyl benzylmethylphosphinate

There total 3 articles about R_p-(-)-menthyl benzylmethylphosphinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

Rp-(-)-menthyl benzylphosphinate + methyl iodide (74-88-4) → Rp-(-)-menthyl benzylmethylphosphinate (126441-54-1)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 55 ℃; for 0.5h;

Reference yield:

benzyldichlorophosphane (4545-85-1) → Rp-(-)-menthyl benzylmethylphosphinate (126441-54-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 2.) water / 1.) diethyl ether, pyridine, 8-10 degC, 30 min; 2.) diethyl ether, pyridine, allowed to warm to 20 degC

2: 75 percent / sodium hydride / dimethylformamide / 0.5 h / 55 °C

With water; sodium hydride; In N,N-dimethyl-formamide;

Reference yield:

(-)-menthol (2216-51-5) → Rp-(-)-menthyl benzylmethylphosphinate (126441-54-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 2.) water / 1.) diethyl ether, pyridine, 8-10 degC, 30 min; 2.) diethyl ether, pyridine, allowed to warm to 20 degC

2: 75 percent / sodium hydride / dimethylformamide / 0.5 h / 55 °C

With water; sodium hydride; In N,N-dimethyl-formamide;

upstream raw materials:

methyl iodide

benzyldichlorophosphane

(-)-menthol

Downstream raw materials:

R(+)-benzyl methyl phenyl phosphine oxide