5-METHYL-4-QUINAZOLONE

Base Information

• Chemical Name: 5-METHYL-4-QUINAZOLONE
• CAS No.: 75844-41-6
• Molecular Formula: C9H8N2O
• Molecular Weight: 160.175
• Hs Code.: 2927000090
• Mol file: 75844-41-6.mol

Synonyms:4-Hydroxy-5-methylquinazoline;5-Methylquinazolin-4-ol;

Chemical Property of 5-METHYL-4-QUINAZOLONE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 224℃
• Refractive Index: 1.644
• Boiling Point: 330.027 °C at 760 mmHg
• PKA: 1.74±0.20(Predicted)
• Flash Point: 153.395 °C
• PSA: 45.75000
• Density: 1.27 g/cm³
• LogP: 1.23150
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

5-Methyl-4-quinazolone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-METHYL-4-QUINAZOLONE

There total 7 articles about 5-METHYL-4-QUINAZOLONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-amino-6-methylbenzoic acid (4389-50-8) + formamide (77287-34-4,77287-35-5,60100-09-6) → 5-methyl-quinazolin-4(3H)-one (75844-41-6)

Guidance literature:

at 140 ℃;

DOI:10.1016/j.ejmech.2012.02.001

Reference yield: 85.0%

methanol (67-56-1) + 2-amino-6-methylbenzamide (1885-31-0) → 5-methyl-quinazolin-4(3H)-one (75844-41-6)

Guidance literature:

With copper(l) iodide; oxygen; caesium carbonate; at 20 ℃; for 16h; Irradiation;

DOI:10.1039/d0ob02234a

Reference yield: 80.0%

2-amino-6-methylbenzoic acid (4389-50-8) + formamidine acetic acid (3473-63-0) → 5-methyl-quinazolin-4(3H)-one (75844-41-6)

Guidance literature:

In ethanol; for 18h; Reflux; Inert atmosphere;

upstream raw materials:

2-amino-6-methylbenzoic acid

formamide

2-methyl-6-nitrobenzoic acid

2-cyano-3-nitrotoluene

Downstream raw materials:

N-benzyl-5-methylquinazolin-4-amine

5-methyl-4-phenoxyquinazoline

4-chloro-5-methylquinazoline