Methyl 2-methoxy-6-(methylamino)nicotinate

Base Information

• Chemical Name: Methyl 2-methoxy-6-(methylamino)nicotinate
• CAS No.: 187480-13-3
• Molecular Formula: C₉H₁₂N₂O₃
• Molecular Weight: 196.206
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID90444691
• Nikkaji Number: J1.403.904J
• Mol file: 187480-13-3.mol

Synonyms:methyl 2-methoxy-6-methylaminopyridine-3-carboxylate;methyl 2-methoxyMAPCA

Chemical Property of Methyl 2-methoxy-6-(methylamino)nicotinate

Chemical Property:

• Melting Point: 138～140℃
• PSA: 60.45000
• LogP: 0.99150
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 196.08479225
• Heavy Atom Count: 14
• Complexity: 199

Purity/Quality:

98%min ^*data from raw suppliers

Methyl 2-methoxy-6-(methylamino)nicotinate >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CNC1=NC(=C(C=C1)C(=O)OC)OC

Technology Process of Methyl 2-methoxy-6-(methylamino)nicotinate

There total 14 articles about Methyl 2-methoxy-6-(methylamino)nicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

methanol (67-56-1) + methyl 2-fluoro-6-methylaminopyridine-3-carboxylate (187480-11-1) → methyl 2-methoxy-6-methylaminopyridine-3-carboxylate (187480-13-3)

Guidance literature:

With potassium tert-butylate; for 2h; Heating;

DOI:10.1248/cpb.48.1847

Reference yield: 90.0%

methylamine (74-89-5) + methyl 2-methoxy-6-(4-methylbenzenesulfinyl)pyridine-3-carboxylate (237390-81-7) → methyl 2-methoxy-6-methylaminopyridine-3-carboxylate (187480-13-3)

Guidance literature:

In ethanol; N,N-dimethyl-formamide; at 60 ℃; for 1h;

DOI:10.1248/cpb.48.1847

Reference yield: 79.0%

2-methoxy-6-methylamino-3-trimethoxymethylpyridine (233585-52-9) → methyl 2-methoxy-6-methylaminopyridine-3-carboxylate (187480-13-3)

Guidance literature:

With hydrogenchloride; In methanol; at 20 ℃; for 0.5h;

DOI:10.1248/cpb.49.1621

upstream raw materials:

methanol

methyl 2-fluoro-6-methylaminopyridine-3-carboxylate

ethyl 2-fluoro-6-(N-methyl-N-pivaloylamino)pyridine-3-carboxylate

methylamine

Downstream raw materials:

methyl 5-bromo-2-methoxy-6-methylaminopyridine-3-carboxylate

5-bromo-2-methoxy-6-methylaminopyridine-3-carboxylic acid