3-Chloro-6-(4-chlorophenyl)pyridazine

Base Information

• Chemical Name: 3-Chloro-6-(4-chlorophenyl)pyridazine
• CAS No.: 58059-29-3
• Molecular Formula: C10H6Cl2N2
• Molecular Weight: 225.077
• Hs Code.: 2933998090
• DSSTox Substance ID: DTXSID30482734
• Nikkaji Number: J2.139.025I
• Wikidata: Q82319375
• Mol file: 58059-29-3.mol

Synonyms:3-Chloro-6-(4-chlorophenyl)pyridazine;58059-29-3;3-chloro-6-(4-chlorophenyl)-pyridazine;3-Chloro-6-(4-chloro-phenyl)-pyridazine;MFCD06801340;Pyridazine,3-chloro-6-(4-chlorophenyl)-;3-(4-chlorophenyl)-6-chloropyridazine;SCHEMBL256008;F1967-0367;DTXSID30482734;ARQKIDKGCMDXKY-UHFFFAOYSA-N;3-chloro-6-(p-chlorophenyl)pyridazine;6-(p-chlorophenyl)-3-chloropyridazine;AKOS005208508;AS-10377;SY239482;CS-0060234;EN300-237962;F52719;A869533

Chemical Property of 3-Chloro-6-(4-chlorophenyl)pyridazine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 200-201 °C(Solv: ethanol (64-17-5))
• Refractive Index: 1.605
• Boiling Point: 400.939 °C at 760 mmHg
• PKA: 0.14±0.10(Predicted)
• Flash Point: 228.615 °C
• Density: 1.364 g/cm³
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 223.9908036
• Heavy Atom Count: 14
• Complexity: 181

Purity/Quality:

97% ^*data from raw suppliers

3-chloro-6-(4-chlorophenyl)pyridazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1C2=NN=C(C=C2)Cl)Cl

Technology Process of 3-Chloro-6-(4-chlorophenyl)pyridazine

There total 12 articles about 3-Chloro-6-(4-chlorophenyl)pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

6-(p-chlorophenyl)-3(2H)-pyridazinone (2166-13-4) → 6-(p-chlorophenyl)-3-chloropyridazine (58059-29-3)

Guidance literature:

With isocyanate de chlorosulfonyle; In various solvent(s); at 60 - 65 ℃; for 3.5h;

Reference yield: 35.7%

3,6-dichlorpyridazine (141-30-0) + 4-Chlorophenylboronic acid (1679-18-1) → 6-(p-chlorophenyl)-3-chloropyridazine (58059-29-3)

Guidance literature:

With sodium carbonate; chloro(di-2-norbornylphosphino)(2'-dimethylamino-1,1'-biphenyl-2-yl)palladium(II); In 1,4-dioxane; water; at 110 ℃; for 3h;

Reference yield:

3,6-dichlorpyridazine (141-30-0) + boronic acid 4-chlorophenyl monoester (274251-56-8) → 3-(4-chloro-phenyl)-6-[4-(2-pyrrolidin-1-yl-ethoxy)-phenylethynyl]-pyridazine + 6-(p-chlorophenyl)-3-chloropyridazine (58059-29-3)

Guidance literature:

With sodium carbonate; Pd(dppf)Cl₂; In 1,4-dioxane; water;

upstream raw materials:

6-(p-chlorophenyl)-3(2H)-pyridazinone

3,6-dichlorpyridazine

(4-chlorophenyl)zinc(II) chloride

4-Chlorophenylboronic acid

Downstream raw materials:

3-(4-hydroxypiperidino)-6-(4-chlorophenyl)pyridazine

3-phenyl-6-(4'-chlorophenyl)-1,2,4-triazolo[4,3-b]pyridazine

6-(4-chloro-phenyl)-3-ethyl-[1,2,4]triazolo[4,3-b]pyridazine

6-(4-chloro-phenyl)-[1,2,4]triazolo[4,3-b]pyridazine