2-[(5-methyl-2-p-tolyl-3H-imidazole-4-carbonyl)-amino]-3-phenyl-propionic acid methyl ester

Base Information

• Chemical Name: 2-[(5-methyl-2-p-tolyl-3H-imidazole-4-carbonyl)-amino]-3-phenyl-propionic acid methyl ester
• CAS No.: 618904-98-6
• Molecular Formula: C₂₂H₂₃N₃O₃
• Molecular Weight: 377.443

Synonyms:2-[(5-methyl-2-p-tolyl-3H-imidazole-4-carbonyl)-amino]-3-phenyl-propionic acid methyl ester

Chemical Property of 2-[(5-methyl-2-p-tolyl-3H-imidazole-4-carbonyl)-amino]-3-phenyl-propionic acid methyl ester

Chemical Property:

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Technology Process of 2-[(5-methyl-2-p-tolyl-3H-imidazole-4-carbonyl)-amino]-3-phenyl-propionic acid methyl ester

There total 2 articles about 2-[(5-methyl-2-p-tolyl-3H-imidazole-4-carbonyl)-amino]-3-phenyl-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

para-methylbenzylamine (104-84-7) + 2-(2-hydroxyimino-3-oxo-butyrylamino)-3-phenylpropionic acid methyl ester (618904-93-1) → 2-[(5-methyl-2-p-tolyl-3H-imidazole-4-carbonyl)-amino]-3-phenyl-propionic acid methyl ester (618904-98-6)

Guidance literature:

With triethylamine; In acetonitrile; at 80 ℃;

DOI:10.1021/ol035455i

Reference yield:

2-(3-oxo-butyrylamino)-3-phenylpropionic acid methyl ester (62973-00-6) → 2-[(5-methyl-2-p-tolyl-3H-imidazole-4-carbonyl)-amino]-3-phenyl-propionic acid methyl ester (618904-98-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / NaNO₂ / acetic acid; H₂O / 0.25 h / 0 °C

2: Et₃N / acetonitrile / 80 °C

With triethylamine; sodium nitrite; In water; acetic acid; acetonitrile;

DOI:10.1021/ol035455i

Reference yield:

2-[(5-methyl-2-p-tolyl-3H-imidazole-4-carbonyl)-amino]-3-phenyl-propionic acid methyl ester (618904-98-6) → 5-methyl-2-p-tolyl-3H-imidazole-4-carboxylic acid (1-hydroxymethyl-2-phenyl-ethyl)-amide

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran;

DOI:10.1021/ol035455i

upstream raw materials:

para-methylbenzylamine

2-(2-hydroxyimino-3-oxo-butyrylamino)-3-phenylpropionic acid methyl ester

2-(3-oxo-butyrylamino)-3-phenylpropionic acid methyl ester

Downstream raw materials:

6-benzyl-1-methyl-3-p-tolyl-6,7-dihydro-5H-imidazo[1,5-a]pyrazin-8-one

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