(S)-2-(4-Benzyloxy-3,5-dichloro-benzoylamino)-3-hydroxy-propionic acid benzyl ester

Base Information

Chemical Name:(S)-2-(4-Benzyloxy-3,5-dichloro-benzoylamino)-3-hydroxy-propionic acid benzyl ester
CAS No.:420107-66-0
Molecular Formula:C₂₄H₂₁Cl₂NO₅
Molecular Weight:474.34
Hs Code.:

Synonyms:(S)-2-(4-Benzyloxy-3,5-dichloro-benzoylamino)-3-hydroxy-propionic acid benzyl ester

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Chemical Property of (S)-2-(4-Benzyloxy-3,5-dichloro-benzoylamino)-3-hydroxy-propionic acid benzyl ester

Chemical Property:

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Technology Process of (S)-2-(4-Benzyloxy-3,5-dichloro-benzoylamino)-3-hydroxy-propionic acid benzyl ester

There total 1 articles about (S)-2-(4-Benzyloxy-3,5-dichloro-benzoylamino)-3-hydroxy-propionic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 60022-62-0,879278-55-4,151651-44-4
L-serine benzyl ester hydrochloride

: 41490-13-5
4-(benzyloxy)-3,5-dichlorobenzoicacid

: 420107-66-0
(S)-2-(4-Benzyloxy-3,5-dichloro-benzoylamino)-3-hydroxy-propionic acid benzyl ester

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1016/S0040-4039(01)02255-9

Reference yield: 74.0%

: 124-63-0
methanesulfonyl chloride

: 420107-66-0
(S)-2-(4-Benzyloxy-3,5-dichloro-benzoylamino)-3-hydroxy-propionic acid benzyl ester

: 420107-73-9
(S)-2-(4-Benzyloxy-3,5-dichloro-benzoylamino)-3-methanesulfonyloxy-propionic acid benzyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃;
DOI:10.1016/S0040-4039(01)02255-9

Reference yield:

: 420107-66-0
(S)-2-(4-Benzyloxy-3,5-dichloro-benzoylamino)-3-hydroxy-propionic acid benzyl ester

: 198710-92-8
(-)-Kaitocephalin

Guidance literature:: Multi-step reaction with 9 steps

1: 74 percent / Et₃N / CH₂Cl₂ / 0 °C

2: 84 percent / NaI / acetone / 20 °C

3: 75 percent / Zn; CuI / tetrahydrofuran; H₂O / 20 °C / ultrasound irradiation

4: 98 percent / Zn; satd. NH₄Cl / ethanol / 90 °C

5: K₂CO₃ / toluene; H₂O

6: methanol / 20 °C

7: 4-methoxy-TEMPO; KBr; satd. NaHCO₃ / NaClO / CH₂Cl₂ / 0 °C

8: NaClO₂; 2-methyl-2-butene; NaH₂PO₄ / isobutanol; H₂O / 20 °C

9: 27 percent / H₂ / Pd(OH)2-C / ethanol; CHCl₃ / 20 °C

With 4-methoxy-TEMPO; sodium chlorite; sodium dihydrogenphosphate; copper(l) iodide; 2-methyl-but-2-ene; hydrogen; sodium hydrogencarbonate; potassium carbonate; ammonium chloride; triethylamine; sodium iodide; potassium bromide; zinc; sodium hypochlorite; palladium hydroxide - carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; 2-methyl-propan-1-ol; chloroform; water; acetone; toluene;
DOI:10.1016/S0040-4039(01)02255-9