N-{2-[4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy]ethyl}-4-methoxybenzene-1-sulfonamide

Base Information

Chemical Name:N-{2-[4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy]ethyl}-4-methoxybenzene-1-sulfonamide
CAS No.:1044871-48-8
Molecular Formula:C₂₇H₂₉N₃O₇S
Molecular Weight:539.609
Hs Code.:

Synonyms:N-{2-[4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy]ethyl}-4-methoxybenzene-1-sulfonamide

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Chemical Property of N-{2-[4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy]ethyl}-4-methoxybenzene-1-sulfonamide

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Technology Process of N-{2-[4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy]ethyl}-4-methoxybenzene-1-sulfonamide

There total 9 articles about N-{2-[4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy]ethyl}-4-methoxybenzene-1-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1044871-46-6
2-(4-(2-aminoethoxy)-3,5-dimethylphenyl)-5,7-dimethoxyquinazolin-4(3H)-one

: 98-68-0
4-methoxy-phenyl-sulphonyl chloride

: 1044871-48-8
N-{2-[4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy]ethyl}-4-methoxybenzene-1-sulfonamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 3h;

Reference yield:

: 21577-57-1
2-amino-4,6-dimethoxybenzoic acid

: 1044871-48-8
N-{2-[4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy]ethyl}-4-methoxybenzene-1-sulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / tetrahydrofuran / 3 h / 20 °C

1.2: 16 h / 20 °C

2.1: p-toluenesulfonic acid monohydrate; sodium hydrogensulfite / N,N-dimethyl acetamide / 1.5 h

3.1: tetrahydrofuran / 17 h / 20 °C

4.1: triethylamine / dichloromethane / 3 h / 20 °C

With 4-methyl-morpholine; p-toluenesulfonic acid monohydrate; benzotriazol-1-ol; sodium hydrogensulfite; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl acetamide;

Reference yield:

: 2233-18-3
4-hydroxy-3,5-dimethylbenzaldehyde

: 1044871-48-8
N-{2-[4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy]ethyl}-4-methoxybenzene-1-sulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 2.5 h / 80 °C

2.1: sodium hydrogensulfite; toluene-4-sulfonic acid / N,N-dimethyl acetamide / 1.5 h / Reflux

2.2: 17 h / 20 °C

3.1: triethylamine / dichloromethane / 3 h / 20 °C

With potassium carbonate; toluene-4-sulfonic acid; sodium hydrogensulfite; triethylamine; sodium iodide; In dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide;