methyl (2S)-1-[(4-methylphenyl)sulfonyl]aziridine-2-carboxylate

Base Information

• Chemical Name: methyl (2S)-1-[(4-methylphenyl)sulfonyl]aziridine-2-carboxylate
• CAS No.: 105424-75-7
• Molecular Formula: C₁₁H₁₃NO₄S
• Molecular Weight: 255.295
• Mol file: 105424-75-7.mol

Synonyms:methyl (2S)-1-[(4-methylphenyl)sulfonyl]aziridine-2-carboxylate

Chemical Property of methyl (2S)-1-[(4-methylphenyl)sulfonyl]aziridine-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (2S)-1-[(4-methylphenyl)sulfonyl]aziridine-2-carboxylate

There total 25 articles about methyl (2S)-1-[(4-methylphenyl)sulfonyl]aziridine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methyl (2S)-3-hydroxy-2-{[(4-methylphenyl)sulfonyl]amino}propanoate (17136-46-8) → methyl (2S)-1-[(4-methylphenyl)sulfonyl]aziridine-2-carboxylate (105424-75-7)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate;

DOI:10.1021/jo962307f

Reference yield: 98.0%

[N-(p-tolylsulfonyl)imino]phenyliodinane (55962-05-5) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → 1-(toluene-4-sulfonyl)-aziridine-2-carboxylic acid methyl ester (105424-75-7,141436-64-8,137595-25-6)

Guidance literature:

With C₁₇H₁₃ClCuN₃O₂; sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate; In dichloromethane; at 0 - 22 ℃; Inert atmosphere;

DOI:10.1021/acs.inorgchem.9b02618

Reference yield: 96.0%

methyl aziridine-2-carboxylate (5950-34-5,118396-26-2,151526-74-8,151526-75-9) + p-toluenesulfonyl chloride (98-59-9) → 1-(toluene-4-sulfonyl)-aziridine-2-carboxylic acid methyl ester (105424-75-7,141436-64-8,137595-25-6)

Guidance literature:

With potassium carbonate; In chloroform; water; at 20 ℃; for 24h;

DOI:10.1007/s10593-021-03034-x

upstream raw materials:

methyl aziridine-2-carboxylate

p-toluenesulfonyl chloride

Methyl 2,3-dibromopropionate

toluene-4-sulfonamide

Downstream raw materials:

(2SR)-methoxycarbonyl-1-tosylpyrrolidine-(3SR,4RS)-diyl carbonate

(2RS)-methoxycarbonyl-1-tosylpyrrolidine-(3SR,4RS)-diyl carbonate

N-[(4-methylphenyl)sulfonyl]-β-alanine methyl ester