Technology Process of 4-[methoxy(phenyl)methyl]-1,2-dibromobenzene
There total 5 articles about 4-[methoxy(phenyl)methyl]-1,2-dibromobenzene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(3,4-dibromophenyl)phenylmethanol;
With
sodium hydride;
In
tetrahydrofuran;
at 0 - 25 ℃;
for 1h;
methyl iodide;
In
tetrahydrofuran;
at 25 ℃;
for 18h;
DOI:10.1002/ejoc.201001217
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium iodide / water; acetone / 0.5 h / 25 °C
2.1: isopropylmagnesium chloride / tetrahydrofuran / 3 h / -78 °C / Inert atmosphere
2.2: -78 - 25 °C / Inert atmosphere
3.1: sodium hydride / tetrahydrofuran / 1 h / 0 - 25 °C
3.2: 18 h / 25 °C
With
isopropylmagnesium chloride; sodium hydride; potassium iodide;
In
tetrahydrofuran; water; acetone;
1.1: Sandmeyer iodination;
DOI:10.1002/ejoc.201001217
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: tetrafluoroboric acid; sodium nitrite / water / 0.5 h / 0 °C
2.1: potassium iodide / water; acetone / 0.5 h / 25 °C
3.1: isopropylmagnesium chloride / tetrahydrofuran / 3 h / -78 °C / Inert atmosphere
3.2: -78 - 25 °C / Inert atmosphere
4.1: sodium hydride / tetrahydrofuran / 1 h / 0 - 25 °C
4.2: 18 h / 25 °C
With
tetrafluoroboric acid; isopropylmagnesium chloride; sodium hydride; potassium iodide; sodium nitrite;
In
tetrahydrofuran; water; acetone;
2.1: Sandmeyer iodination;
DOI:10.1002/ejoc.201001217
