3-(3-(N-(2-(tert-butyldimethylsilyloxy)ethyl)methylsulfonamido)pyridin-4-yl)-N-(2-phenylpropan-2-yl)benzamide

Base Information

Chemical Name:3-(3-(N-(2-(tert-butyldimethylsilyloxy)ethyl)methylsulfonamido)pyridin-4-yl)-N-(2-phenylpropan-2-yl)benzamide
CAS No.:1215106-23-2
Molecular Formula:C₃₀H₄₁N₃O₄SSi
Molecular Weight:567.825
Hs Code.:

Synonyms:3-(3-(N-(2-(tert-butyldimethylsilyloxy)ethyl)methylsulfonamido)pyridin-4-yl)-N-(2-phenylpropan-2-yl)benzamide

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Chemical Property of 3-(3-(N-(2-(tert-butyldimethylsilyloxy)ethyl)methylsulfonamido)pyridin-4-yl)-N-(2-phenylpropan-2-yl)benzamide

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Technology Process of 3-(3-(N-(2-(tert-butyldimethylsilyloxy)ethyl)methylsulfonamido)pyridin-4-yl)-N-(2-phenylpropan-2-yl)benzamide

There total 7 articles about 3-(3-(N-(2-(tert-butyldimethylsilyloxy)ethyl)methylsulfonamido)pyridin-4-yl)-N-(2-phenylpropan-2-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1215106-22-1
3-(3-(methylsulfonamido)pyridin-4-yl)-N-(2-phenylpropan-2-yl)benzamide

: 86864-60-0
2-(tert-butyldimethylsilyloxy)ethyl bromide

: 1215106-23-2
3-(3-(N-(2-(tert-butyldimethylsilyloxy)ethyl)methylsulfonamido)pyridin-4-yl)-N-(2-phenylpropan-2-yl)benzamide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 4h;

Reference yield:

: 25487-66-5
3-Carboxyphenylboronic acid

: 1215106-23-2
3-(3-(N-(2-(tert-butyldimethylsilyloxy)ethyl)methylsulfonamido)pyridin-4-yl)-N-(2-phenylpropan-2-yl)benzamide

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 15 h / 100 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / HATU / N,N-dimethyl-formamide / 1 h / 20 °C

3: hydrogen / palladium 10% on activated carbon / water; methanol / 2 h

4: triethylamine / dichloromethane / 20 °C

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 60 °C

6: potassium carbonate / N,N-dimethyl-formamide / 4 h / 80 °C

With tetrabutyl ammonium fluoride; hydrogen; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; HATU; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 13091-23-1
4-chloro-3-nitropyridine

: 1215106-23-2
3-(3-(N-(2-(tert-butyldimethylsilyloxy)ethyl)methylsulfonamido)pyridin-4-yl)-N-(2-phenylpropan-2-yl)benzamide

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 15 h / 100 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / HATU / N,N-dimethyl-formamide / 1 h / 20 °C

3: hydrogen / palladium 10% on activated carbon / water; methanol / 2 h

4: triethylamine / dichloromethane / 20 °C

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 60 °C

6: potassium carbonate / N,N-dimethyl-formamide / 4 h / 80 °C

With tetrabutyl ammonium fluoride; hydrogen; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; HATU; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;