Technology Process of 3-(3-(methylsulfonamido)pyridin-4-yl)-N-(2-phenylpropan-2-yl)benzamide
There total 7 articles about 3-(3-(methylsulfonamido)pyridin-4-yl)-N-(2-phenylpropan-2-yl)benzamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
tetrabutyl ammonium fluoride;
In
tetrahydrofuran;
at 60 ℃;
for 18h;
- Guidance literature:
-
3-(3-aminopyridin-4-yl)-N-(2-phenylpropan-2-yl)benzamide; methanesulfonyl chloride;
With
triethylamine;
In
dichloromethane;
at 20 ℃;
for 1.05h;
With
tetrabutyl ammonium fluoride;
In
tetrahydrofuran;
at 60 ℃;
for 18h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / 15 h / 100 °C / Inert atmosphere
2: N-ethyl-N,N-diisopropylamine / HATU / N,N-dimethyl-formamide / 1 h / 20 °C
3: hydrogen / palladium 10% on activated carbon / water; methanol / 2 h
4: triethylamine / dichloromethane / 20 °C
5: tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 60 °C
With
tetrabutyl ammonium fluoride; hydrogen; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine;
tetrakis(triphenylphosphine) palladium(0); palladium 10% on activated carbon; HATU;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;