2-benzyl-5-methoxyphthalimide

Base Information

• Chemical Name: 2-benzyl-5-methoxyphthalimide
• CAS No.: 1007455-12-0
• Molecular Formula: C₁₆H₁₃NO₃
• Molecular Weight: 267.284
• Mol file: 1007455-12-0.mol

Synonyms:2-benzyl-5-methoxyisoindoline-1,3-dione

Chemical Property of 2-benzyl-5-methoxyphthalimide

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

2-Benzyl-5-methoxyisoindole-1,3-dione ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-benzyl-5-methoxyphthalimide

There total 3 articles about 2-benzyl-5-methoxyphthalimide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-benzyl-5-hydroxyisoindoline-1,3-dione (3997-85-1) + methyl iodide (74-88-4) → 2-benzyl-5-methoxyisoindoline-1,3-dione (1007455-12-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 19 - 24 ℃;

Reference yield: 95.0%

5-methoxyisobenzofuran-1,3-dione (28281-76-7) + benzylamine (100-46-9) → 2-benzyl-5-methoxyisoindoline-1,3-dione (1007455-12-0)

Guidance literature:

With acetic acid; at 120 ℃; for 2h; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.orglett.8b02287

Reference yield:

dimethyl 4-methoxyphtalate (22895-19-8) + benzylamine (100-46-9) → 2-benzyl-5-methoxyisoindoline-1,3-dione (1007455-12-0)

Guidance literature:

In toluene; Heating / reflux; Dean-Stark trap;

upstream raw materials:

2-benzyl-5-hydroxyisoindoline-1,3-dione

methyl iodide

dimethyl 4-methoxyphtalate

benzylamine

Downstream raw materials:

N-benzylisoindolin-5-yl methyl ether

7-methoxy-3-phenylisoquinoline

2-benzyl-5-methoxy-1,1,3,3-tetramethylisoindoline

Refernces

• 1、 Ding, Guangni,Wu, Xiaoyu,Lu, Bin,Lu, Wenkui,Zhang, Zhaoguo,Xie, Xiaomin. "Tri(pentaflurophenyl)borane-catalyzed reduction of cyclic imides with hydrosilanes: Synthesis of pyrrolidines". supporting information. p. 1144 - 1150. Retrieved 2018/02/17.
• 2、 -. "BETA-BLOCKERS HAVING ANTIOXIDANT AND NO-DONOR ACTIVITY". Page/Page column 52; 70. . Retrieved 2010/02/07.