Technology Process of 1-(pent-4-enoyl)-3-[1(R)-(4-phenylbutoxy)ethyl]azetidine
There total 6 articles about 1-(pent-4-enoyl)-3-[1(R)-(4-phenylbutoxy)ethyl]azetidine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
pent-4-enoic acid;
With
benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 0.166667h;
Inert atmosphere;
3-[(1R)-(4-phenylbutoxy)ethyl]azetidine;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 15h;
Inert atmosphere;
DOI:10.1021/jm200723m
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C
1.2: 0.25 h
2.1: sodium hydride / N,N-dimethyl-formamide / 0 °C / Inert atmosphere
2.2: 0 - 20 °C / Inert atmosphere
3.1: lithium aluminium tetrahydride; aluminum (III) chloride / diethyl ether / 4 h / 0 °C / Inert atmosphere; Reflux
4.1: ammonium cerium (IV) nitrate / water; acetonitrile / 1 h / 70 °C
5.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.17 h / 20 °C / Inert atmosphere
5.2: 15 h / 20 °C / Inert atmosphere
With
aluminum (III) chloride; lithium aluminium tetrahydride; ammonium cerium (IV) nitrate; tetrabutyl ammonium fluoride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; sodium hydride; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; diethyl ether; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm200723m
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydride / N,N-dimethyl-formamide / 0 °C / Inert atmosphere
1.2: 0 - 20 °C / Inert atmosphere
2.1: lithium aluminium tetrahydride; aluminum (III) chloride / diethyl ether / 4 h / 0 °C / Inert atmosphere; Reflux
3.1: ammonium cerium (IV) nitrate / water; acetonitrile / 1 h / 70 °C
4.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.17 h / 20 °C / Inert atmosphere
4.2: 15 h / 20 °C / Inert atmosphere
With
aluminum (III) chloride; lithium aluminium tetrahydride; ammonium cerium (IV) nitrate; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; sodium hydride; N-ethyl-N,N-diisopropylamine;
In
diethyl ether; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm200723m
