1-benzyloxycarbonyl-4-(4,5-bis(4-methoxyphenyl)oxazol-2-yl)-4-hydroxymethylpiperidine

Base Information

• Chemical Name: 1-benzyloxycarbonyl-4-(4,5-bis(4-methoxyphenyl)oxazol-2-yl)-4-hydroxymethylpiperidine
• CAS No.: 951744-84-6
• Molecular Formula: C₃₁H₃₂N₂O₆
• Molecular Weight: 528.605
• Mol file: 951744-84-6.mol

Synonyms:1-benzyloxycarbonyl-4-(4,5-bis(4-methoxyphenyl)oxazol-2-yl)-4-hydroxymethylpiperidine

Chemical Property of 1-benzyloxycarbonyl-4-(4,5-bis(4-methoxyphenyl)oxazol-2-yl)-4-hydroxymethylpiperidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-benzyloxycarbonyl-4-(4,5-bis(4-methoxyphenyl)oxazol-2-yl)-4-hydroxymethylpiperidine

There total 7 articles about 1-benzyloxycarbonyl-4-(4,5-bis(4-methoxyphenyl)oxazol-2-yl)-4-hydroxymethylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

methyl 1-benzyloxycarbonyl-4-(4,5-bis(4-methoxyphenyl)oxazol-2-yl)-4-piperidinecarboxylate (951744-37-9) → 1-benzyloxycarbonyl-4-(4,5-bis(4-methoxyphenyl)oxazol-2-yl)-4-hydroxymethylpiperidine (951744-84-6)

Guidance literature:

With lithium borohydride; In tetrahydrofuran; at 20 ℃; for 17h;

Reference yield:

2-bromo-1,2-bis(4-methoxyphenyl)ethanone (27895-95-0) → 1-benzyloxycarbonyl-4-(4,5-bis(4-methoxyphenyl)oxazol-2-yl)-4-hydroxymethylpiperidine (951744-84-6)

Guidance literature:

Multi-step reaction with 3 steps

1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

2: ammonium acetate; acetic acid / 17 h / 90 °C

3: lithium borohydride / tetrahydrofuran / 17 h / 20 °C

With lithium borohydride; ammonium acetate; caesium carbonate; acetic acid; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

1,4-di(4-methoxyphenyl)ethanone (120-44-5) → 1-benzyloxycarbonyl-4-(4,5-bis(4-methoxyphenyl)oxazol-2-yl)-4-hydroxymethylpiperidine (951744-84-6)

Guidance literature:

Multi-step reaction with 4 steps

1: pyridinium hydrobromide perbromide / dichloromethane / 1 h / 20 °C

2: caesium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

3: ammonium acetate; acetic acid / 17 h / 90 °C

4: lithium borohydride / tetrahydrofuran / 17 h / 20 °C

With lithium borohydride; pyridinium hydrobromide perbromide; ammonium acetate; caesium carbonate; acetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

methyl 1-benzyloxycarbonyl-4-(4,5-bis(4-methoxyphenyl)oxazol-2-yl)-4-piperidinecarboxylate

2-bromo-1,2-bis(4-methoxyphenyl)ethanone

1,4-di(4-methoxyphenyl)ethanone

(1,2-Bis(4-methoxyphenyl)-2-oxoethyl) 1-benzyloxycarbonyl-4-methoxycarbonyl-4-piperidinecarboxylate

Downstream raw materials:

4-acetoxymethyl-1-benzyloxycarbonyl-4-(4,5-bis(4-methoxyphenyl)oxazol-2-yl)piperidine

Refernces