3-N-BOC-3-(METHYLAMINO)PIPERIDINE

Base Information

• Chemical Name: 3-N-BOC-3-(METHYLAMINO)PIPERIDINE
• CAS No.: 172478-01-2
• Molecular Formula: C11H22N2O2
• Molecular Weight: 214.30
• Hs Code.: 2933399090
• Mol file: 172478-01-2.mol

Synonyms:Carbamicacid, methyl-3-piperidinyl-, 1,1-dimethylethyl ester (9CI);3-[(tert-Butoxycarbonyl)(methyl)amino]piperidine;3-(N-Boc-N-methyl)aminopiperidine;tert-Butyl methyl(piperidin-3-yl)carbamate;

Chemical Property of 3-N-BOC-3-(METHYLAMINO)PIPERIDINE

Chemical Property:

• Vapor Pressure: 0.00242mmHg at 25°C
• Refractive Index: 1.485
• Boiling Point: 287.863 °C at 760 mmHg
• PKA: 9.74±0.10(Predicted)
• Flash Point: 127.895 °C
• PSA: 41.57000
• Density: 1.019 g/cm³
• LogP: 1.93410
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

tert-ButylMethyl(piperidin-3-yl)carbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-N-BOC-3-(METHYLAMINO)PIPERIDINE

There total 7 articles about 3-N-BOC-3-(METHYLAMINO)PIPERIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-benzyl-3-<(t-butyloxycarbonyl)methylamino>-piperidine (172477-99-5) → 3-<(t-butyloxycarbonyl)methylamino>-piperidine (172478-01-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; Ambient temperature;

DOI:10.1016/0040-4020(95)00716-L

Reference yield:

pyridin-3-ylmethyl-carbamic acid tert-butyl ester (1279817-03-6) → 3-<(t-butyloxycarbonyl)methylamino>-piperidine (172478-01-2)

Guidance literature:

With hydrogen; 5% rhodium-on-charcoal; In ethanol; at 25 ℃; for 27h; under 3102.97 Torr; Paar apparatus;

Reference yield:

3-t-butoxycarbonylaminopiperidin-1-carboxylic acid benzyl ester (406213-47-6) + methyl iodide (74-88-4) → 3-<(t-butyloxycarbonyl)methylamino>-piperidine (172478-01-2)

Guidance literature:

3-t-butoxycarbonylaminopiperidin-1-carboxylic acid benzyl ester; methyl iodide; With sodium hydride; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 4h;

With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃; for 5h;

upstream raw materials:

1-benzyl-3-<(t-butyloxycarbonyl)methylamino>-piperidine

1-benzyl-3-piperidone

1-benzyl-N-methylpiperidin-3-amine

pyridin-3-ylmethyl-carbamic acid tert-butyl ester

Downstream raw materials:

3-methylamino-1-propionyl-piperidine