Technology Process of 6-benzyloxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester
There total 6 articles about 6-benzyloxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium carbonate;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 12h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: ammonium acetate; acetic acid / 12 h / 100 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 12 h / 0 - 80 °C
3.1: hydrogenchloride / water / 1 h / 60 °C
4.1: hydrogenchloride / isopropyl alcohol; water / 18 h / 20 °C
5.1: hydrogen bromide; water / 5 h / Reflux
6.1: triethylamine / tetrahydrofuran; water
7.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 1 h / 0 - 20 °C
7.2: 1 h
With
hydrogenchloride; lithium aluminium tetrahydride; ammonium acetate; water; hydrogen bromide; sodium hydride; acetic acid; triethylamine;
In
tetrahydrofuran; water; N,N-dimethyl-formamide; isopropyl alcohol; mineral oil;
DOI:10.1021/jm3014103
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: hydrogenchloride / water / 1 h / 60 °C
2.1: hydrogenchloride / isopropyl alcohol; water / 18 h / 20 °C
3.1: hydrogen bromide; water / 5 h / Reflux
4.1: triethylamine / tetrahydrofuran; water
5.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 1 h / 0 - 20 °C
5.2: 1 h
With
hydrogenchloride; water; hydrogen bromide; sodium hydride; triethylamine;
In
tetrahydrofuran; water; N,N-dimethyl-formamide; isopropyl alcohol; mineral oil;
DOI:10.1021/jm3014103
