2-Ethyl-1,2,3,4-tetrahydro-1-phenylpyrrolo[1,2-a]pyrazine

Base Information

• Chemical Name: 2-Ethyl-1,2,3,4-tetrahydro-1-phenylpyrrolo[1,2-a]pyrazine
• CAS No.: 73627-30-2
• Molecular Formula: C₁₅H₁₈N₂
• Molecular Weight: 226.321
• DSSTox Substance ID: DTXSID601197111

Synonyms:SCHEMBL6369627;2-Ethyl-1,2,3,4-tetrahydro-1-phenylpyrrolo[1,2-a]pyrazine;DTXSID601197111;73627-30-2

Chemical Property of 2-Ethyl-1,2,3,4-tetrahydro-1-phenylpyrrolo[1,2-a]pyrazine

Chemical Property:

• XLogP3: 2.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 226.146998583
• Heavy Atom Count: 17
• Complexity: 247

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCN1CCN2C=CC=C2C1C3=CC=CC=C3

Technology Process of 2-Ethyl-1,2,3,4-tetrahydro-1-phenylpyrrolo[1,2-a]pyrazine

There total 3 articles about 2-Ethyl-1,2,3,4-tetrahydro-1-phenylpyrrolo[1,2-a]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

N-Ethyl-1-(2-aminoethyl)-pyrrole (73627-29-9) + benzaldehyde (100-52-7) → 2-Ethyl-1-phenyl-1,2,3,4-tetrahydropyrrolo<1,2-a>pyrazine (73627-30-2)

Guidance literature:

In acetic acid; for 48h; Ambient temperature;

DOI:10.1055/s-1981-29499

Reference yield:

N-[2-(1H-pyrrol-1-yl)ethyl]acetamide (73627-16-4) → 2-Ethyl-1-phenyl-1,2,3,4-tetrahydropyrrolo<1,2-a>pyrazine (73627-30-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / LiAlH₄ / tetrahydrofuran / Heating

2: 52 percent / acetic acid / 48 h / Ambient temperature

With lithium aluminium tetrahydride; In tetrahydrofuran; acetic acid;

DOI:10.1055/s-1981-29499

Reference yield:

C15H17N2(1+)*I(1-) → 2-Ethyl-1-phenyl-1,2,3,4-tetrahydropyrrolo<1,2-a>pyrazine (73627-30-2)

Guidance literature:

C₁₅H₁₇N₂⁽¹⁺⁾*I^(1-); With sodium tetrahydroborate; In methanol;

With water;

DOI:10.1016/j.tet.2010.04.104

upstream raw materials:

N-Ethyl-1-(2-aminoethyl)-pyrrole

benzaldehyde

N-[2-(1H-pyrrol-1-yl)ethyl]acetamide

Downstream raw materials:

2-ethyl-1-phenyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-6-carbaldehyde

1-(2-ethyl-1-phenyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-6-yl)-2,2,2-trifluoroethanone

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