Nα-Acetylglutamine methyl ester

Base Information

• Chemical Name: Nα-Acetylglutamine methyl ester
• CAS No.: 56159-64-9
• Molecular Formula: C₈H₁₄N₂O₄
• Molecular Weight: 202.21
• Mol file: 56159-64-9.mol

Synonyms:methyl 2-acetamido-5-amino-5-oxopentanoate

Chemical Property of Nα-Acetylglutamine methyl ester

Chemical Property:

• Boiling Point: 483.2±35.0 °C(Predicted)
• PKA: 14.61±0.46(Predicted)
• Density: 1.181±0.06 g/cm3(Predicted)

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Nα-Acetylglutamine methyl ester

There total 1 articles about Nα-Acetylglutamine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

methanol (67-56-1) + N-acetyl-L-glutamine (2490-97-3,193158-96-2) → methyl 2-acetamido-5-amino-5-oxopentanoate (56159-64-9)

Guidance literature:

With acetyl chloride; at 20 ℃; for 24h;

Reference yield:

methyl 2-acetamido-5-amino-5-oxopentanoate (56159-64-9) → N-AcTrp (1218-34-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 61 percent / p-TsCl / pyridine

2: 88 percent / hydrogen / Raney-Ni deactivated with 3percent Pb / H₂O; acetic acid

4: 1.) 0.1 N HCl; 2.) 1 N NaOH / 1.) reflux, 1 h;

With hydrogenchloride; sodium hydroxide; hydrogen; p-toluenesulfonyl chloride; Raney-Ni deactivated with 3percent Pb; In pyridine; water; acetic acid;

Reference yield:

methyl 2-acetamido-5-amino-5-oxopentanoate (56159-64-9) → (S)-2-Acetylamino-5-(phenyl-hydrazono)-pentanoic acid methyl ester (85148-76-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 61 percent / p-TsCl / pyridine

2: 88 percent / hydrogen / Raney-Ni deactivated with 3percent Pb / H₂O; acetic acid

With hydrogen; p-toluenesulfonyl chloride; Raney-Ni deactivated with 3percent Pb; In pyridine; water; acetic acid;

upstream raw materials:

methanol

N-acetyl-L-glutamine

Downstream raw materials:

(S)-2-Acetylamino-5-(phenyl-hydrazono)-pentanoic acid methyl ester

N-AcTrp

Refernces