3-(2-amino-5-(4-chloro-2-(trifluoromethyl)phenoxy)thiazol-4-yl)benzonitrile

Base Information

Chemical Name:3-(2-amino-5-(4-chloro-2-(trifluoromethyl)phenoxy)thiazol-4-yl)benzonitrile
CAS No.:1391980-14-5
Molecular Formula:C₁₇H₉ClF₃N₃OS
Molecular Weight:395.792
Hs Code.:

Synonyms:3-(2-amino-5-(4-chloro-2-(trifluoromethyl)phenoxy)thiazol-4-yl)benzonitrile

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Chemical Property of 3-(2-amino-5-(4-chloro-2-(trifluoromethyl)phenoxy)thiazol-4-yl)benzonitrile

Chemical Property:

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Technology Process of 3-(2-amino-5-(4-chloro-2-(trifluoromethyl)phenoxy)thiazol-4-yl)benzonitrile

There total 6 articles about 3-(2-amino-5-(4-chloro-2-(trifluoromethyl)phenoxy)thiazol-4-yl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 53903-51-8
2-trifluoromethyl-4-chlorophenol

: 1391980-09-8
5-bromo-4-(3-cyanophenyl)thiazol-2-amine

: 1391980-14-5
3-(2-amino-5-(4-chloro-2-(trifluoromethyl)phenoxy)thiazol-4-yl)benzonitrile

Guidance literature:: With caesium carbonate; In acetone; at 45 ℃; for 4h;

Reference yield:

: 1535-76-8
4-amino-2-(trifluoromethyl)phenol

: 1391980-14-5
3-(2-amino-5-(4-chloro-2-(trifluoromethyl)phenoxy)thiazol-4-yl)benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium nitrite; hydrogenchloride / acetonitrile; water / 0 °C

1.2: 6 h / 100 °C

2.1: caesium carbonate / acetone / 4 h / 45 °C

With hydrogenchloride; caesium carbonate; sodium nitrite; In water; acetone; acetonitrile;
DOI:10.1016/j.bmc.2015.07.068

Reference yield:

: 654-76-2
1-methoxy-4-nitro-2-(trifluoromethyl)benzene

: 1391980-14-5
3-(2-amino-5-(4-chloro-2-(trifluoromethyl)phenoxy)thiazol-4-yl)benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium chloride; N,N-dimethyl-formamide / 5 h / 160 °C

2.1: zinc; ammonium formate / methanol; water / 3 h / 80 °C

3.1: sodium nitrite; hydrogenchloride / acetonitrile; water / 0 °C

3.2: 6 h / 100 °C

4.1: caesium carbonate / acetone / 4 h / 45 °C

With hydrogenchloride; ammonium formate; caesium carbonate; N,N-dimethyl-formamide; lithium chloride; zinc; sodium nitrite; In methanol; water; acetone; acetonitrile;
DOI:10.1016/j.bmc.2015.07.068