1-[N-(tert-butoxycarbonyl)aminoacetyl]-4-(3-phenylpropan-1-yl)piperazine

Base Information

• Chemical Name: 1-[N-(tert-butoxycarbonyl)aminoacetyl]-4-(3-phenylpropan-1-yl)piperazine
• CAS No.: 198895-71-5
• Molecular Formula: C₂₀H₃₁N₃O₃
• Molecular Weight: 361.484

Synonyms:1-[N-(tert-butoxycarbonyl)aminoacetyl]-4-(3-phenylpropan-1-yl)piperazine

Chemical Property of 1-[N-(tert-butoxycarbonyl)aminoacetyl]-4-(3-phenylpropan-1-yl)piperazine

Chemical Property:

Purity/Quality:

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Technology Process of 1-[N-(tert-butoxycarbonyl)aminoacetyl]-4-(3-phenylpropan-1-yl)piperazine

There total 3 articles about 1-[N-(tert-butoxycarbonyl)aminoacetyl]-4-(3-phenylpropan-1-yl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

BOC-glycine (4530-20-5) + 1-(3-phenylpropyl)-piperazine dihydrochloride + 1,8-diazabicyclo[5.4.0]unde-7-cene + 1-hydroxybenzotriazol-hydrate (80029-43-2,123333-53-9) + 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride (25952-53-8) → 1-[N-(tert-butoxycarbonyl)aminoacetyl]-4-(3-phenylpropan-1-yl)piperazine (198895-71-5)

Guidance literature:

With sodium hydrogencarbonate; triethylamine; In water; ethyl acetate; acetonitrile;

Reference yield:

phenylpropyl chloride (104-52-9) → 1-[N-(tert-butoxycarbonyl)aminoacetyl]-4-(3-phenylpropan-1-yl)piperazine (198895-71-5)

Guidance literature:

Multi-step reaction with 2 steps

1: dimethylformamide / 48 h / Ambient temperature

2: 1.) dicyclohexylcarbodiimide / 1.) CH₂Cl₂, RT, 10 min, 2.) CH₂Cl₂, RT

With dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;

DOI:10.1021/jm980143k

Reference yield:

BOC-glycine (4530-20-5) + 1-(3-phenylpropyl)piperazine (55455-92-0) → 1-[N-(tert-butoxycarbonyl)aminoacetyl]-4-(3-phenylpropan-1-yl)piperazine (198895-71-5)

Guidance literature:

With dicyclohexyl-carbodiimide; Multistep reaction; 1.) CH₂Cl₂, RT, 10 min, 2.) CH₂Cl₂, RT;

DOI:10.1021/jm980143k

upstream raw materials:

BOC-glycine

1-(3-phenylpropyl)piperazine

phenylpropyl chloride

1-hydroxybenzotriazol-hydrate

Downstream raw materials:

2-Amino-1-[4-(3-phenyl-propyl)-piperazin-1-yl]-ethanone

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