(S)-3-[N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-guanidino]-1-(3-methoxycarbonyl-benzyl)-1-methyl-piperidinium chloride

Base Information

Chemical Name:(S)-3-[N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-guanidino]-1-(3-methoxycarbonyl-benzyl)-1-methyl-piperidinium chloride
CAS No.:1583272-44-9
Molecular Formula:C₂₁H₂₈ClN₈O₃*Cl
Molecular Weight:511.411
Hs Code.:

Synonyms:(S)-3-[N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-guanidino]-1-(3-methoxycarbonyl-benzyl)-1-methyl-piperidinium chloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-3-[N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-guanidino]-1-(3-methoxycarbonyl-benzyl)-1-methyl-piperidinium chloride

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Technology Process of (S)-3-[N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-guanidino]-1-(3-methoxycarbonyl-benzyl)-1-methyl-piperidinium chloride

There total 6 articles about (S)-3-[N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-guanidino]-1-(3-methoxycarbonyl-benzyl)-1-methyl-piperidinium chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1610619-91-4
(S)-3-{3-[N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-guanidino]-piperidin-1-ylmethyl}-benzoic acid methyl ester

: 74-88-4
methyl iodide

: 1583272-44-9
(S)-3-[N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-guanidino]-1-(3-methoxycarbonyl-benzyl)-1-methyl-piperidinium chloride

Guidance literature:: In N,N-dimethyl-formamide; acetone; at 20 ℃;

Reference yield:

: 4878-36-8
3,5-diamino-6-chloro-pyrazine-2-carboxylic acid

: 1583272-44-9
(S)-3-[N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-guanidino]-1-(3-methoxycarbonyl-benzyl)-1-methyl-piperidinium chloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: trifluorormethanesulfonic acid / tert-butyl alcohol / 1 h / Cooling with ice

1.2: 4 h / 20 °C

2.1: sodium hydroxide / water; dichloromethane; tetrahydrofuran / 20 °C

3.1: triethylamine / N,N-dimethyl-formamide; isopropyl alcohol / 70 °C

3.2: 2 h / 20 °C

4.1: triethylamine / N,N-dimethyl-formamide / 6 h / 20 °C

5.1: N,N-dimethyl-formamide; acetone / 20 °C

With trifluorormethanesulfonic acid; triethylamine; sodium hydroxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; acetone; tert-butyl alcohol;

Reference yield:

: 1583272-58-5
N-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-N'-piperidin-3-yl-guanidine

: 1583272-44-9
(S)-3-[N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-guanidino]-1-(3-methoxycarbonyl-benzyl)-1-methyl-piperidinium chloride

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / N,N-dimethyl-formamide / 6 h / 20 °C

2: N,N-dimethyl-formamide; acetone / 20 °C

With triethylamine; In N,N-dimethyl-formamide; acetone;