(2R)-2-{1-[(1S)-1-carboxy-2-(5-phenyl-oxazol-2-yl)-ethylcarbamoyl]-cyclopentylmethyl}-pentanoic acid

Base Information

Chemical Name:(2R)-2-{1-[(1S)-1-carboxy-2-(5-phenyl-oxazol-2-yl)-ethylcarbamoyl]-cyclopentylmethyl}-pentanoic acid
CAS No.:719307-70-7
Molecular Formula:C₂₄H₃₀N₂O₆
Molecular Weight:442.512
Hs Code.:

Synonyms:(2R)-2-{1-[(1S)-1-carboxy-2-(5-phenyl-oxazol-2-yl)-ethylcarbamoyl]-cyclopentylmethyl}-pentanoic acid

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Chemical Property of (2R)-2-{1-[(1S)-1-carboxy-2-(5-phenyl-oxazol-2-yl)-ethylcarbamoyl]-cyclopentylmethyl}-pentanoic acid

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Technology Process of (2R)-2-{1-[(1S)-1-carboxy-2-(5-phenyl-oxazol-2-yl)-ethylcarbamoyl]-cyclopentylmethyl}-pentanoic acid

There total 5 articles about (2R)-2-{1-[(1S)-1-carboxy-2-(5-phenyl-oxazol-2-yl)-ethylcarbamoyl]-cyclopentylmethyl}-pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 719307-83-2
(2S)-2-{1-[(1S)-1-carboxy-2-(3-phenyl-[1,2,4]oxadiazol-5-yl)-ethylcarbamoyl]-cyclopentylmethyl}-4-methoxy-butyric acid ethyl ester

: 719307-70-7
(2R)-2-{1-[(1S)-1-carboxy-2-(5-phenyl-oxazol-2-yl)-ethylcarbamoyl]-cyclopentylmethyl}-pentanoic acid

Guidance literature:: With sodium hydroxide; In 1,4-dioxane; at 20 ℃; for 18h;

Reference yield:

: 719308-09-5
(2S)-2-benzyloxycarbonylamino-3-(5-phenyl-oxazol-2-yl)-propionic acid ethyl ester

: 719307-70-7
(2R)-2-{1-[(1S)-1-carboxy-2-(5-phenyl-oxazol-2-yl)-ethylcarbamoyl]-cyclopentylmethyl}-pentanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen bromide; acetic acid

2: 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane

3: trifluoroacetic acid / dichloromethane

4: water; sodium hydroxide / 1,4-dioxane

With 4-methyl-morpholine; water; hydrogen bromide; benzotriazol-1-ol; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; sodium hydroxide; In 1,4-dioxane; dichloromethane;
DOI:10.1016/j.bmcl.2011.03.109

Reference yield:

: 755753-54-9
(2S)-2-amino-3-(5-phenyl-oxazol-2-yl)-propionic acid ethyl ester

: 719307-70-7
(2R)-2-{1-[(1S)-1-carboxy-2-(5-phenyl-oxazol-2-yl)-ethylcarbamoyl]-cyclopentylmethyl}-pentanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane

2: trifluoroacetic acid / dichloromethane

3: water; sodium hydroxide / 1,4-dioxane

With 4-methyl-morpholine; water; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; sodium hydroxide; In 1,4-dioxane; dichloromethane;
DOI:10.1016/j.bmcl.2011.03.109