(2S)-2-benzyloxycarbonylamino-3-(5-phenyl-oxazol-2-yl)-propionic acid ethyl ester

Base Information

• Chemical Name: (2S)-2-benzyloxycarbonylamino-3-(5-phenyl-oxazol-2-yl)-propionic acid ethyl ester
• CAS No.: 719308-09-5
• Molecular Formula: C₂₂H₂₂N₂O₅
• Molecular Weight: 394.427

Synonyms:(2S)-2-benzyloxycarbonylamino-3-(5-phenyl-oxazol-2-yl)-propionic acid ethyl ester

Chemical Property of (2S)-2-benzyloxycarbonylamino-3-(5-phenyl-oxazol-2-yl)-propionic acid ethyl ester

Chemical Property:

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Technology Process of (2S)-2-benzyloxycarbonylamino-3-(5-phenyl-oxazol-2-yl)-propionic acid ethyl ester

There total 7 articles about (2S)-2-benzyloxycarbonylamino-3-(5-phenyl-oxazol-2-yl)-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2S)-2-benzyloxycarbonylamino-N-(2-oxo-2-phenyl-ethyl)-succinamic acid ethyl ester (719307-95-6) → (2S)-2-benzyloxycarbonylamino-3-(5-phenyl-oxazol-2-yl)-propionic acid ethyl ester (719308-09-5)

Guidance literature:

With trichlorophosphate; In toluene; at 100 ℃; for 1.5h;

Reference yield:

(S)-3-(benzyloxycarbonylamino)-4-ethoxy-4-oxobutanoic acid (4668-43-3) → (2S)-2-benzyloxycarbonylamino-3-(5-phenyl-oxazol-2-yl)-propionic acid ethyl ester (719308-09-5)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride; triethylamine / N,N-dimethyl-formamide

2: trichlorophosphate / toluene / 100 °C

With thionyl chloride; triethylamine; trichlorophosphate; In N,N-dimethyl-formamide; toluene;

DOI:10.1016/j.bmcl.2011.03.109

Reference yield:

C22H24N2O7 → (2S)-2-benzyloxycarbonylamino-3-(5-phenyl-oxazol-2-yl)-propionic acid ethyl ester (719308-09-5)

Guidance literature:

With trichlorophosphate; In toluene; at 100 ℃;

DOI:10.1016/j.bmcl.2011.03.109

upstream raw materials:

(2S)-2-benzyloxycarbonylamino-N-(2-oxo-2-phenyl-ethyl)-succinamic acid ethyl ester

(S)-3-(benzyloxycarbonylamino)-4-ethoxy-4-oxobutanoic acid

N-benzyloxycarbonyl-L-aspartic acid anhydride

Downstream raw materials:

(2S)-2-benzyloxycarbonylamino-3-(5-phenyl-oxazol-2-yl)-propionic acid

(2S)-2-amino-3-(5-phenyl-oxazol-2-yl)-propionic acid ethyl ester

(2R)-2-{1-[(1S)-1-ethoxycarbonyl-2-(5-phenyloxazol-2-yl)-ethylcarbamoyl]-cyclopentylmethyl}-pentanoic acid ter-butyl ester

C₂₆H₃₄N₂O₇

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