(2R)-2-{1-[(1S)-1-ethoxycarbonyl-2-(5-phenyloxazol-2-yl)-ethylcarbamoyl]-cyclopentylmethyl}-pentanoic acid ter-butyl ester

Base Information

Chemical Name:(2R)-2-{1-[(1S)-1-ethoxycarbonyl-2-(5-phenyloxazol-2-yl)-ethylcarbamoyl]-cyclopentylmethyl}-pentanoic acid ter-butyl ester
CAS No.:719308-63-1
Molecular Formula:C₃₀H₄₂N₂O₆
Molecular Weight:526.673
Hs Code.:

Synonyms:(2R)-2-{1-[(1S)-1-ethoxycarbonyl-2-(5-phenyloxazol-2-yl)-ethylcarbamoyl]-cyclopentylmethyl}-pentanoic acid ter-butyl ester

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Chemical Property of (2R)-2-{1-[(1S)-1-ethoxycarbonyl-2-(5-phenyloxazol-2-yl)-ethylcarbamoyl]-cyclopentylmethyl}-pentanoic acid ter-butyl ester

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Technology Process of (2R)-2-{1-[(1S)-1-ethoxycarbonyl-2-(5-phenyloxazol-2-yl)-ethylcarbamoyl]-cyclopentylmethyl}-pentanoic acid ter-butyl ester

There total 5 articles about (2R)-2-{1-[(1S)-1-ethoxycarbonyl-2-(5-phenyloxazol-2-yl)-ethylcarbamoyl]-cyclopentylmethyl}-pentanoic acid ter-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (R)-1-(2-tert-butoxycarbonylpentyl)cyclopentanecarboxylic acid

: 719308-31-3
(2S)-2-amino-3-(5-phenyl-oxazol-2-yl)-propionic acid ethyl ester hydrochloride

: 719308-63-1
(2R)-2-{1-[(1S)-1-ethoxycarbonyl-2-(5-phenyloxazol-2-yl)-ethylcarbamoyl]-cyclopentylmethyl}-pentanoic acid ter-butyl ester

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 18h;

Reference yield:

: C₂₂H₂₄N₂O₇

: 719308-63-1
(2R)-2-{1-[(1S)-1-ethoxycarbonyl-2-(5-phenyloxazol-2-yl)-ethylcarbamoyl]-cyclopentylmethyl}-pentanoic acid ter-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: trichlorophosphate / toluene / 100 °C

2: hydrogen bromide; acetic acid

3: 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane

With 4-methyl-morpholine; hydrogen bromide; benzotriazol-1-ol; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trichlorophosphate; In dichloromethane; toluene;
DOI:10.1016/j.bmcl.2011.03.109

Reference yield:

: 719308-09-5
(2S)-2-benzyloxycarbonylamino-3-(5-phenyl-oxazol-2-yl)-propionic acid ethyl ester

: 719308-63-1
(2R)-2-{1-[(1S)-1-ethoxycarbonyl-2-(5-phenyloxazol-2-yl)-ethylcarbamoyl]-cyclopentylmethyl}-pentanoic acid ter-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen bromide; acetic acid

2: 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane

With 4-methyl-morpholine; hydrogen bromide; benzotriazol-1-ol; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane;
DOI:10.1016/j.bmcl.2011.03.109