diethyl 1-(2,2-difluoro-3-{[(4-methylphenyl)sulfonyl]oxy}propyl)-1H-indole-2,6-dicarboxylate

Base Information

• Chemical Name: diethyl 1-(2,2-difluoro-3-{[(4-methylphenyl)sulfonyl]oxy}propyl)-1H-indole-2,6-dicarboxylate
• CAS No.: 1311369-17-1
• Molecular Formula: C₂₄H₂₅F₂NO₇S
• Molecular Weight: 509.528
• Mol file: 1311369-17-1.mol

Synonyms:diethyl 1-(2,2-difluoro-3-{[(4-methylphenyl)sulfonyl]oxy}propyl)-1H-indole-2,6-dicarboxylate

Chemical Property of diethyl 1-(2,2-difluoro-3-{[(4-methylphenyl)sulfonyl]oxy}propyl)-1H-indole-2,6-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl 1-(2,2-difluoro-3-{[(4-methylphenyl)sulfonyl]oxy}propyl)-1H-indole-2,6-dicarboxylate

There total 4 articles about diethyl 1-(2,2-difluoro-3-{[(4-methylphenyl)sulfonyl]oxy}propyl)-1H-indole-2,6-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

2,2-difluoropropane-1,3-diyl bis(4-methylbenzenesulfonate) (857280-01-4) + diethyl 1H-indole-2,6-dicarboxylate (107516-75-6) → diethyl 1-(2,2-difluoro-3-{[(4-methylphenyl)sulfonyl]oxy}propyl)-1H-indole-2,6-dicarboxylate (1311369-17-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 135 ℃; for 1h; Microwave irradiation;

DOI:10.1016/j.bmcl.2011.10.030

Reference yield:

ethyl 4-methyl-3-nitro-benzoate (19013-15-1) → diethyl 1-(2,2-difluoro-3-{[(4-methylphenyl)sulfonyl]oxy}propyl)-1H-indole-2,6-dicarboxylate (1311369-17-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium ethanolate / ethanol / 16 h / 20 °C

1.2: pH 7

2.1: zinc; acetic acid / water / 1 h / 85 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 135 °C / Microwave irradiation

With sodium ethanolate; potassium carbonate; acetic acid; zinc; In ethanol; water; N,N-dimethyl-formamide;

Reference yield:

ethyl 4-(3-ethoxy-2,3-dioxopropyl)-3-nitrobenzoate (861384-91-0) → diethyl 1-(2,2-difluoro-3-{[(4-methylphenyl)sulfonyl]oxy}propyl)-1H-indole-2,6-dicarboxylate (1311369-17-1)

Guidance literature:

Multi-step reaction with 2 steps

1: zinc; acetic acid / water / 1 h / 85 °C

2: potassium carbonate / N,N-dimethyl-formamide / 1 h / 135 °C / Microwave irradiation

With potassium carbonate; acetic acid; zinc; In water; N,N-dimethyl-formamide;

upstream raw materials:

ethyl 4-methyl-3-nitro-benzoate

4-methyl-3-nitrobenzoic acid

ethyl 4-(3-ethoxy-2,3-dioxopropyl)-3-nitrobenzoate

2,2-difluoropropane-1,3-diyl bis(4-methylbenzenesulfonate)