[5-chloro-2-(methylthio)pyrimidin-4-yl](5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)methanone

Base Information

• Chemical Name: [5-chloro-2-(methylthio)pyrimidin-4-yl](5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)methanone
• CAS No.: 1000369-59-4
• Molecular Formula: C₁₆H₁₃ClN₄O₂S
• Molecular Weight: 360.824
• Mol file: 1000369-59-4.mol

Synonyms:[5-chloro-2-(methylthio)pyrimidin-4-yl](5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)methanone

Chemical Property of [5-chloro-2-(methylthio)pyrimidin-4-yl](5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)methanone

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of [5-chloro-2-(methylthio)pyrimidin-4-yl](5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)methanone

There total 2 articles about [5-chloro-2-(methylthio)pyrimidin-4-yl](5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

edaravone (89-25-8) + 5-chloro-2-(methylsulfanyl)pyrimidine-4-carbonyl chloride (79686-02-5) → [5-chloro-2-(methylthio)pyrimidin-4-yl](5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)methanone (1000369-59-4)

Guidance literature:

With calcium hydroxide; In 1,4-dioxane; for 3h; Heating;

DOI:10.3390/12010060

Reference yield:

5-chloro-2-(methylthio)pyrimidine-4-carboxylic acid (61727-33-1) → [5-chloro-2-(methylthio)pyrimidin-4-yl](5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)methanone (1000369-59-4)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / dimethylformamide; toluene / 3 h / Heating

2: 59 percent / calcium hydroxide / dioxane / 3 h / Heating

With calcium hydroxide; thionyl chloride; In 1,4-dioxane; N,N-dimethyl-formamide; toluene;

DOI:10.3390/12010060

Reference yield: 67.0%

[5-chloro-2-(methylthio)pyrimidin-4-yl](5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)methanone (1000369-59-4) → 3-methyl-6-(methylthio)-1-phenylpyrazolo[4',3':5,6]pyrano[3,2-d]pyrimidin-4(1H)-one

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; Heating;

DOI:10.3390/12010060

upstream raw materials:

edaravone

5-chloro-2-(methylsulfanyl)pyrimidine-4-carbonyl chloride

5-chloro-2-(methylthio)pyrimidine-4-carboxylic acid