4-(4-(2-amino-3-(5-hydroxypyridin-2-yl)-propanamido)phenyl)-N-hydroxybutanamide

Base Information

Chemical Name:4-(4-(2-amino-3-(5-hydroxypyridin-2-yl)-propanamido)phenyl)-N-hydroxybutanamide
CAS No.:1351934-96-7
Molecular Formula:C₁₈H₂₂N₄O₄
Molecular Weight:358.397
Hs Code.:

Synonyms:4-(4-(2-amino-3-(5-hydroxypyridin-2-yl)-propanamido)phenyl)-N-hydroxybutanamide

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Chemical Property of 4-(4-(2-amino-3-(5-hydroxypyridin-2-yl)-propanamido)phenyl)-N-hydroxybutanamide

Chemical Property:

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Technology Process of 4-(4-(2-amino-3-(5-hydroxypyridin-2-yl)-propanamido)phenyl)-N-hydroxybutanamide

There total 6 articles about 4-(4-(2-amino-3-(5-hydroxypyridin-2-yl)-propanamido)phenyl)-N-hydroxybutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1351934-94-5
C₂₃H₃₀N₄O₆

: 1351934-96-7
4-(4-(2-amino-3-(5-hydroxypyridin-2-yl)-propanamido)phenyl)-N-hydroxybutanamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 4h;

Reference yield:

: 20637-09-6
methyl 4-(4-aminophenyl)butanoate

: 1351934-96-7
4-(4-(2-amino-3-(5-hydroxypyridin-2-yl)-propanamido)phenyl)-N-hydroxybutanamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 2 h / 20 °C

2.1: water; lithium hydroxide / tetrahydrofuran / 2 h / 60 °C

2.2: pH 2 / Acidic conditions

3.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 0.5 h / 0 °C

3.2: 0.5 h / 0 - 20 °C

4.1: hydrogen / palladium 10% on activated carbon / methanol / 4 h / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

With water; hydrogen; chloroformic acid ethyl ester; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; lithium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 1350618-43-7
R(-)-tert-butyl N-{2-[5-(benzyloxy)pyridin-2-yl]-1-({4-[3-(hydroxycarbamoyl)propyl]phenyl}carbamoyl)ethyl}carbamate

: 1351934-96-7
4-(4-(2-amino-3-(5-hydroxypyridin-2-yl)-propanamido)phenyl)-N-hydroxybutanamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 4 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

With hydrogen; trifluoroacetic acid; palladium 10% on activated carbon; In methanol; dichloromethane;