4-METHYTHIO-PIPERIDINE

Base Information

• Chemical Name: 4-METHYTHIO-PIPERIDINE
• CAS No.: 767270-41-7
• Molecular Formula: C6H13NS
• Molecular Weight: 131.242
• Hs Code.: 2933399090
• Mol file: 767270-41-7.mol

Synonyms:4-METHYTHIO-PIPERIDINE;4-Meththiopiperidine

Chemical Property of 4-METHYTHIO-PIPERIDINE

Chemical Property:

• Vapor Pressure: 0.29mmHg at 25°C
• Refractive Index: 1.511
• Boiling Point: 202.601 °C at 760 mmHg
• PKA: 9.83±0.10(Predicted)
• Flash Point: 76.331 °C
• PSA: 37.33000
• Density: 0.998 g/cm³
• LogP: 1.43020

Purity/Quality:

97% ^*data from raw suppliers

4-Methylthiopiperidine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-METHYTHIO-PIPERIDINE

There total 4 articles about 4-METHYTHIO-PIPERIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methylsulfanylpiperidine-1-carboxylic acid tert-butyl ester (208245-69-6) → 4-methylsulfanyl-piperidine (767270-41-7)

Guidance literature:

With trifluoroacetic acid; at 20 ℃; for 1h;

DOI:10.1248/cpb.49.822

Reference yield:

4-HYDROXYPIPERIDINE (5382-16-1) → 4-methylsulfanyl-piperidine (767270-41-7)

Guidance literature:

Multi-step reaction with 4 steps

1: CH₂Cl₂; dioxane / 2 h / 20 °C

2: 2.59 g / Et₃N / CH₂Cl₂ / 13 h / 20 °C

3: 59 percent / dimethylformamide / 2 h / 80 °C

4: TFA / 1 h / 20 °C

With triethylamine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1248/cpb.49.822

Reference yield:

t-butyl 4-hydroxy piperidine-1-carboxylate (109384-19-2) → 4-methylsulfanyl-piperidine (767270-41-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 2.59 g / Et₃N / CH₂Cl₂ / 13 h / 20 °C

2: 59 percent / dimethylformamide / 2 h / 80 °C

3: TFA / 1 h / 20 °C

With triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1248/cpb.49.822

upstream raw materials:

4-methylsulfanylpiperidine-1-carboxylic acid tert-butyl ester

4-HYDROXYPIPERIDINE

t-butyl 4-hydroxy piperidine-1-carboxylate

1-(tert-butoxycarbonyl)piperidin-4-yl methanesulfonate

Downstream raw materials:

(E)-N-(4-((3-chloro-4-fluorophenyl)amino)thieno[2,3-d]pyrimidin-6-yl)-4-(4-(methylthio)piperidin-1-yl)but-2-enamide