(4E,8E,12Z)-10-Benzenesulfonyl-14-[3,4-dimethyl-5-(tetrahydro-pyran-2-yloxy)-2-(2-trimethylsilanyl-ethoxymethoxy)-phenyl]-4,8,12-trimethyl-tetradeca-4,8,12-trien-1-ol

Base Information

Chemical Name:(4E,8E,12Z)-10-Benzenesulfonyl-14-[3,4-dimethyl-5-(tetrahydro-pyran-2-yloxy)-2-(2-trimethylsilanyl-ethoxymethoxy)-phenyl]-4,8,12-trimethyl-tetradeca-4,8,12-trien-1-ol
CAS No.:201004-62-8
Molecular Formula:C₄₂H₆₄O₇SSi
Molecular Weight:741.117
Hs Code.:

(4E,8E,12Z)-10-Benzenesulfonyl-14-[3,4-dimethyl-5-(tetrahydro-pyran-2-yloxy)-2-(2-trimethylsilanyl-ethoxymethoxy)-phenyl]-4,8,12-trimethyl-tetradeca-4,8,12-trien-1-ol

Synonyms:(4E,8E,12Z)-10-Benzenesulfonyl-14-[3,4-dimethyl-5-(tetrahydro-pyran-2-yloxy)-2-(2-trimethylsilanyl-ethoxymethoxy)-phenyl]-4,8,12-trimethyl-tetradeca-4,8,12-trien-1-ol

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Chemical Property of (4E,8E,12Z)-10-Benzenesulfonyl-14-[3,4-dimethyl-5-(tetrahydro-pyran-2-yloxy)-2-(2-trimethylsilanyl-ethoxymethoxy)-phenyl]-4,8,12-trimethyl-tetradeca-4,8,12-trien-1-ol

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Technology Process of (4E,8E,12Z)-10-Benzenesulfonyl-14-[3,4-dimethyl-5-(tetrahydro-pyran-2-yloxy)-2-(2-trimethylsilanyl-ethoxymethoxy)-phenyl]-4,8,12-trimethyl-tetradeca-4,8,12-trien-1-ol

There total 4 articles about (4E,8E,12Z)-10-Benzenesulfonyl-14-[3,4-dimethyl-5-(tetrahydro-pyran-2-yloxy)-2-(2-trimethylsilanyl-ethoxymethoxy)-phenyl]-4,8,12-trimethyl-tetradeca-4,8,12-trien-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 184763-00-6
S-((2E,6E)-10-hydroxy-3,7-dimethyldeca-2,6-dien-1-yl)benzenesulfone

: 201004-61-7
{2-[6-((Z)-4-Chloro-3-methyl-but-2-enyl)-2,3-dimethyl-4-(tetrahydro-pyran-2-yloxy)-phenoxymethoxy]-ethyl}-trimethyl-silane

: 201004-62-8
(4E,8E,12Z)-10-Benzenesulfonyl-14-[3,4-dimethyl-5-(tetrahydro-pyran-2-yloxy)-2-(2-trimethylsilanyl-ethoxymethoxy)-phenyl]-4,8,12-trimethyl-tetradeca-4,8,12-trien-1-ol

Guidance literature:: With n-butyllithium; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; 1.) -50 deg C, 30 min; 2.) 4 deg C, 20 h;
DOI:10.1002/(SICI)1099-0690(199801)1998:1<43::AID-EJOC43>3.0.CO;2-L

Reference yield:

: 184762-94-5
[3,4-Dimethyl-5-(tetrahydro-pyran-2-yloxy)-2-(2-trimethylsilanyl-ethoxymethoxy)-phenyl]-acetaldehyde

: 201004-62-8
(4E,8E,12Z)-10-Benzenesulfonyl-14-[3,4-dimethyl-5-(tetrahydro-pyran-2-yloxy)-2-(2-trimethylsilanyl-ethoxymethoxy)-phenyl]-4,8,12-trimethyl-tetradeca-4,8,12-trien-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 81 percent / 18-crown-6-acetonitrile complex, potassium bis(trimethylsilyl)amide / tetrahydrofuran; toluene / 0.5 h / -78 °C

2: 85 percent / LiAlH₄ / diethyl ether / 1 h / 0 °C

3: 94 percent / lithium chloride, sym-collidine, methanesulfonyl chloride / dimethylformamide / 1 h / 0 °C

4: 85 percent / 1.) butyllithium / tetrahydrofuran; hexamethylphosphoric acid triamide; hexane / 1.) -50 deg C, 30 min; 2.) 4 deg C, 20 h

With 2,4,6-trimethyl-pyridine; lithium aluminium tetrahydride; n-butyllithium; potassium hexamethylsilazane; methanesulfonyl chloride; 18-crown-6 complexed with acetonitrile; lithium chloride; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; hexane; N,N-dimethyl-formamide; toluene;
DOI:10.1002/(SICI)1099-0690(199801)1998:1<43::AID-EJOC43>3.0.CO;2-L

Reference yield:

: 201004-60-6
(Z)-4-[3,4-Dimethyl-5-(tetrahydro-pyran-2-yloxy)-2-(2-trimethylsilanyl-ethoxymethoxy)-phenyl]-2-methyl-but-2-en-1-ol

: 201004-62-8
(4E,8E,12Z)-10-Benzenesulfonyl-14-[3,4-dimethyl-5-(tetrahydro-pyran-2-yloxy)-2-(2-trimethylsilanyl-ethoxymethoxy)-phenyl]-4,8,12-trimethyl-tetradeca-4,8,12-trien-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / lithium chloride, sym-collidine, methanesulfonyl chloride / dimethylformamide / 1 h / 0 °C

2: 85 percent / 1.) butyllithium / tetrahydrofuran; hexamethylphosphoric acid triamide; hexane / 1.) -50 deg C, 30 min; 2.) 4 deg C, 20 h

With 2,4,6-trimethyl-pyridine; n-butyllithium; methanesulfonyl chloride; lithium chloride; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; N,N-dimethyl-formamide;
DOI:10.1002/(SICI)1099-0690(199801)1998:1<43::AID-EJOC43>3.0.CO;2-L