((R)-1-Benzylcarbamoyl-2,2-dimethyl-propyl)-carbamic acid 4-nitro-phenyl ester

Base Information

Chemical Name:((R)-1-Benzylcarbamoyl-2,2-dimethyl-propyl)-carbamic acid 4-nitro-phenyl ester
CAS No.:268556-63-4
Molecular Formula:C₂₀H₂₃N₃O₅
Molecular Weight:385.42
Hs Code.:

Synonyms:((R)-1-Benzylcarbamoyl-2,2-dimethyl-propyl)-carbamic acid 4-nitro-phenyl ester

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Chemical Property of ((R)-1-Benzylcarbamoyl-2,2-dimethyl-propyl)-carbamic acid 4-nitro-phenyl ester

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Technology Process of ((R)-1-Benzylcarbamoyl-2,2-dimethyl-propyl)-carbamic acid 4-nitro-phenyl ester

There total 4 articles about ((R)-1-Benzylcarbamoyl-2,2-dimethyl-propyl)-carbamic acid 4-nitro-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 268556-62-3
(R)-N-benzyl 2-amino-3,3-dimethylbutanamide

: 7693-46-1
4-Nitrophenyl chloroformate

: 268556-63-4
((R)-1-Benzylcarbamoyl-2,2-dimethyl-propyl)-carbamic acid 4-nitro-phenyl ester

Guidance literature:: With pyridine; In dichloromethane; for 0.5h;
DOI:10.1021/ol005636+

Reference yield:

: (1-benzylcarbamoyl-2,2-dimethyl-propyl)-carbamic acid 9H-fluoren-9-ylmethyl ester

: 268556-63-4
((R)-1-Benzylcarbamoyl-2,2-dimethyl-propyl)-carbamic acid 4-nitro-phenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 895 mg / Et₂NH / methanol / 0.42 h

2: 94 percent / pyridine / CH₂Cl₂ / 0.5 h

With pyridine; diethylamine; In methanol; dichloromethane; 1: deFmoc / 2: amide formation;
DOI:10.1021/ol005636+

Reference yield:

: 112720-39-5
(R)-tert-leucine hydrochloride

: 268556-63-4
((R)-1-Benzylcarbamoyl-2,2-dimethyl-propyl)-carbamic acid 4-nitro-phenyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 78 percent

2.1: DIPEA; HBTU / acetonitrile / 0.02 h

2.2: acetonitrile / 2 h

3.1: 895 mg / Et₂NH / methanol / 0.42 h

4.1: 94 percent / pyridine / CH₂Cl₂ / 0.5 h

With pyridine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; diethylamine; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; acetonitrile; 1.1: Acylation / 2.1: Substitution / 2.2: Substitution / 3.1: deFmoc / 4.1: amide formation;
DOI:10.1021/ol005636+