4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)-3-methylbenzoic acid

Base Information

Chemical Name:4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)-3-methylbenzoic acid
CAS No.:1064195-72-7
Molecular Formula:C₂₄H₂₃NO₅
Molecular Weight:405.45
Hs Code.:

Synonyms:4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)-3-methylbenzoic acid

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Chemical Property of 4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)-3-methylbenzoic acid

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Technology Process of 4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)-3-methylbenzoic acid

There total 7 articles about 4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)-3-methylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1064195-71-6
methyl 4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)-3-methylbenzoate

: 1064195-72-7
4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)-3-methylbenzoic acid

Guidance literature:: methyl 4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)-3-methylbenzoate; With lithium hydroxide; water; In tetrahydrofuran; methanol; at 20 ℃; for 60h;

With hydrogenchloride; In water;

Reference yield:

: 1064195-70-5
methyl 4-(4,9-diethoxy-1-hydroxy-3-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)-3-methylbenzoate

: 1064195-72-7
4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)-3-methylbenzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: triethylsilane; trifluoroacetic acid / dichloromethane

2: water; lithium hydroxide / tetrahydrofuran; methanol

With triethylsilane; water; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.bmcl.2010.12.014

Reference yield:

: 18595-14-7
methyl 4-amino-3-methylbenzoate

: 1064195-72-7
4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)-3-methylbenzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: acetic acid / Reflux

2: sodium tetrahydroborate / tetrahydrofuran; methanol

3: triethylsilane; trifluoroacetic acid / dichloromethane

4: water; lithium hydroxide / tetrahydrofuran; methanol

With triethylsilane; sodium tetrahydroborate; water; acetic acid; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.bmcl.2010.12.014