4,9-diethoxy-2-[4-(hydroxymethyl)-2-methylphenyl]-2,3-dihydro-1H-benzo[f]isoindol-1-one

Base Information

Chemical Name:4,9-diethoxy-2-[4-(hydroxymethyl)-2-methylphenyl]-2,3-dihydro-1H-benzo[f]isoindol-1-one
CAS No.:1064195-73-8
Molecular Formula:C₂₄H₂₅NO₄
Molecular Weight:391.467
Hs Code.:

Synonyms:4,9-diethoxy-2-[4-(hydroxymethyl)-2-methylphenyl]-2,3-dihydro-1H-benzo[f]isoindol-1-one

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Chemical Property of 4,9-diethoxy-2-[4-(hydroxymethyl)-2-methylphenyl]-2,3-dihydro-1H-benzo[f]isoindol-1-one

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Technology Process of 4,9-diethoxy-2-[4-(hydroxymethyl)-2-methylphenyl]-2,3-dihydro-1H-benzo[f]isoindol-1-one

There total 8 articles about 4,9-diethoxy-2-[4-(hydroxymethyl)-2-methylphenyl]-2,3-dihydro-1H-benzo[f]isoindol-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.7%

: 1064195-72-7
4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)-3-methylbenzoic acid

: 1064195-73-8
4,9-diethoxy-2-[4-(hydroxymethyl)-2-methylphenyl]-2,3-dihydro-1H-benzo[f]isoindol-1-one

Guidance literature:: 4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)-3-methylbenzoic acid; With dimethyl sulfide borane; at 20 ℃; for 4h;

With methanol;

Reference yield:

: 1064195-70-5
methyl 4-(4,9-diethoxy-1-hydroxy-3-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)-3-methylbenzoate

: 1064195-73-8
4,9-diethoxy-2-[4-(hydroxymethyl)-2-methylphenyl]-2,3-dihydro-1H-benzo[f]isoindol-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: triethylsilane; trifluoroacetic acid / dichloromethane

2: water; lithium hydroxide / tetrahydrofuran; methanol

3: dimethylsulfide borane complex / tetrahydrofuran

With triethylsilane; dimethylsulfide borane complex; water; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.bmcl.2010.12.014

Reference yield:

: 1064195-71-6
methyl 4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)-3-methylbenzoate

: 1064195-73-8
4,9-diethoxy-2-[4-(hydroxymethyl)-2-methylphenyl]-2,3-dihydro-1H-benzo[f]isoindol-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: water; lithium hydroxide / tetrahydrofuran; methanol

2: dimethylsulfide borane complex / tetrahydrofuran

With dimethylsulfide borane complex; water; lithium hydroxide; In tetrahydrofuran; methanol;
DOI:10.1016/j.bmcl.2010.12.014