N-Boc-4-Dimethylaminopiperidine

Base Information

• Chemical Name: N-Boc-4-Dimethylaminopiperidine
• CAS No.: 412293-88-0
• Molecular Formula: C12H24N2O2
• Molecular Weight: 228.335
• Hs Code.: 2933399090
• Mol file: 412293-88-0.mol

Synonyms:4-(Dimethylamino)-1-(tert-butoxycarbonyl)piperidine;N-tert-Butoxycarbonyl-4-dimethylaminopiperidine;

Chemical Property of N-Boc-4-Dimethylaminopiperidine

Chemical Property:

• Vapor Pressure: 0.002mmHg at 25°C
• Refractive Index: 1.49
• Boiling Point: 295.431 °C at 760 mmHg
• Flash Point: 132.472 °C
• PSA: 32.78000
• Density: 1.012 g/cm³
• LogP: 1.88540
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl4-(dimethylamino)piperidine-1-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-Boc-4-Dimethylaminopiperidine

There total 2 articles about N-Boc-4-Dimethylaminopiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.31%

N,N-dimethylammonium chloride (506-59-2) + N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) → 4-dimethylaminopiperidine-1-carboxylic acid tert-butyl ester (412293-88-0)

Guidance literature:

With sodium cyanoborohydride; acetic acid; In methanol; at 5 ℃; for 16h;

Reference yield:

N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) + dimethyl amine (124-40-3) → 4-dimethylaminopiperidine-1-carboxylic acid tert-butyl ester (412293-88-0)

Guidance literature:

With 10% Pd/C; hydrogen; In methanol; water; at 50 ℃; for 0.5h; under 14711.4 Torr; Autoclave;

DOI:10.1080/00397910802372533

Reference yield: 85.3%

4-dimethylaminopiperidine-1-carboxylic acid tert-butyl ester (412293-88-0) → 4-(dimethylamino)piperidine dihydrochloride (4876-59-9,172281-90-2)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; dichloromethane; water; for 8h; Cooling with ice;

upstream raw materials:

N-tert-butyloxycarbonylpiperidin-4-one

dimethyl amine

N,N-dimethylammonium chloride

Downstream raw materials:

4-(dimethylamino)piperidine dihydrochloride