4-[3-(3,4,5-Trichlorophenyl)-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-yl]-2-(trifluoro-methyl)benzonitrile

Base Information

Chemical Name:4-[3-(3,4,5-Trichlorophenyl)-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-yl]-2-(trifluoro-methyl)benzonitrile
CAS No.:1303518-43-5
Molecular Formula:C₁₉H₉Cl₃F₆N₂
Molecular Weight:485.643
Hs Code.:

Synonyms:4-[3-(3,4,5-Trichlorophenyl)-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-yl]-2-(trifluoro-methyl)benzonitrile

Suppliers and Price of 4-[3-(3,4,5-Trichlorophenyl)-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-yl]-2-(trifluoro-methyl)benzonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-[3-(3,4,5-Trichlorophenyl)-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-yl]-2-(trifluoro-methyl)benzonitrile

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-[3-(3,4,5-Trichlorophenyl)-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-yl]-2-(trifluoro-methyl)benzonitrile

There total 8 articles about 4-[3-(3,4,5-Trichlorophenyl)-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-yl]-2-(trifluoro-methyl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 864736-87-8
1,2,3-trichloro-5-(1,1,1-trifluoroprop-2-en-2-yl)benzene

: C₁₄H₁₇F₃N₂SSi

: 1303518-43-5
4-[3-(3,4,5-Trichlorophenyl)-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-yl]-2-(trifluoro-methyl)benzonitrile

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at -5 - 20 ℃; for 20.5h; Inert atmosphere;

Reference yield:

: 1303518-38-8
4-formyl-3-(trifluoromethyl)-N-[(trimethylsilyl)methyl]benzamide

: 1303518-43-5
4-[3-(3,4,5-Trichlorophenyl)-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-yl]-2-(trifluoro-methyl)benzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: hydroxylamine hydrochloride; sodium acetate / ethanol; water / 20 °C

2: methanesulfonyl chloride / 1,2-dichloro-ethane / 5.33 h / Cooling with ice; Reflux

3: Lawessons reagent / toluene / 1 h / 85 °C

4: potassium tert-butylate / tetrahydrofuran / 0.5 h / -60 °C

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 20.5 h / -5 - 20 °C / Inert atmosphere

With Lawessons reagent; hydroxylamine hydrochloride; potassium tert-butylate; tetrabutyl ammonium fluoride; sodium acetate; methanesulfonyl chloride; In tetrahydrofuran; ethanol; water; 1,2-dichloro-ethane; toluene;

Reference yield:

: 1303518-39-9
4-[(E)-(hydroxyimino)methyl]-3-(trifluoromethyl)-N-[(trimethylsilyl)methyl]benzamide

: 1303518-43-5
4-[3-(3,4,5-Trichlorophenyl)-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-yl]-2-(trifluoro-methyl)benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: methanesulfonyl chloride / 1,2-dichloro-ethane / 5.33 h / Cooling with ice; Reflux

2: Lawessons reagent / toluene / 1 h / 85 °C

3: potassium tert-butylate / tetrahydrofuran / 0.5 h / -60 °C

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 20.5 h / -5 - 20 °C / Inert atmosphere

With Lawessons reagent; potassium tert-butylate; tetrabutyl ammonium fluoride; methanesulfonyl chloride; In tetrahydrofuran; 1,2-dichloro-ethane; toluene;