2'-(triisopropylsilyloxy)-3'-dephenyl-3'-(isobutenyl)-7-(methyldisulfanyl-propanoyl)-docetaxel

Base Information

Chemical Name:2'-(triisopropylsilyloxy)-3'-dephenyl-3'-(isobutenyl)-7-(methyldisulfanyl-propanoyl)-docetaxel
CAS No.:653587-21-4
Molecular Formula:C₅₄H₈₁NO₁₅S₂Si
Molecular Weight:1076.45
Hs Code.:

Synonyms:2'-(triisopropylsilyloxy)-3'-dephenyl-3'-(isobutenyl)-7-(methyldisulfanyl-propanoyl)-docetaxel

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2'-(triisopropylsilyloxy)-3'-dephenyl-3'-(isobutenyl)-7-(methyldisulfanyl-propanoyl)-docetaxel

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Technology Process of 2'-(triisopropylsilyloxy)-3'-dephenyl-3'-(isobutenyl)-7-(methyldisulfanyl-propanoyl)-docetaxel

There total 2 articles about 2'-(triisopropylsilyloxy)-3'-dephenyl-3'-(isobutenyl)-7-(methyldisulfanyl-propanoyl)-docetaxel which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 138148-59-1
3-Methyldisulfanyl-propionic acid

: 653587-20-3
2'-(triisopropylsilyloxy)-3'-dephenyl-3'-(isobutenyl)-docetaxel

: 653587-21-4
2'-(triisopropylsilyloxy)-3'-dephenyl-3'-(isobutenyl)-7-(methyldisulfanyl-propanoyl)-docetaxel

Guidance literature:: With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; at 20 ℃;
DOI:10.1016/j.bmcl.2004.05.027

Reference yield:

: 485801-37-4
3'-dephenyl-3'-(2-methylprop-1-enyl)-7-triethylsilyl-2'-triisopropylsilyldocetaxel

: 653587-21-4
2'-(triisopropylsilyloxy)-3'-dephenyl-3'-(isobutenyl)-7-(methyldisulfanyl-propanoyl)-docetaxel

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / aq. HCl / 16 h / 20 °C

2: 74 percent / DMAP; EDC / 20 °C

With hydrogenchloride; dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide;
DOI:10.1016/j.bmcl.2004.05.027