tert-Butyl-(2-aMino-1-hydroxyethyl)piperidine-1-carboxylate

Base Information

• Chemical Name: tert-Butyl-(2-aMino-1-hydroxyethyl)piperidine-1-carboxylate
• CAS No.: 301221-57-8
• Molecular Formula: C₁₂H₂₄N₂O₃
• Molecular Weight: 244.334
• Mol file: 301221-57-8.mol

Synonyms:tert-butyl 4-(2-amino-1-hydroxyethyl)piperidine-1-carboxylate?

Chemical Property of tert-Butyl-(2-aMino-1-hydroxyethyl)piperidine-1-carboxylate

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 383.2±12.0 °C(Predicted)
• PKA: 12.62±0.35(Predicted)
• Density: 1.103±0.06 g/cm3 (20 oC 760 Torr)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl 4-(2-amino-1-hydroxyethyl)-piperidine-1-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-Butyl-(2-aMino-1-hydroxyethyl)piperidine-1-carboxylate

There total 4 articles about tert-Butyl-(2-aMino-1-hydroxyethyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

tert-butyl 4-(1-hydroxy-2-nitroethyl)piperidine-1-carboxylate (301221-56-7) → tert-butyl 4-(2-amino-1-hydroxyethyl)piperidine-1-carboxylate? (301221-57-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; under 2585.81 Torr;

Reference yield:

rac-tert-butyl 4-[cyano(hydroxy)methyl]piperidine-1-carboxylate (913642-47-4) → tert-butyl 4-(2-amino-1-hydroxyethyl)piperidine-1-carboxylate? (301221-57-8)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

Reference yield:

tert butyl 4-formylpiperidine-1-carboxylate (137076-22-3) → tert-butyl 4-(2-amino-1-hydroxyethyl)piperidine-1-carboxylate? (301221-57-8)

Guidance literature:

Multi-step reaction with 2 steps

1: DBU / tetrahydrofuran

2: H₂ / Pd/C / methanol

With hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; palladium on activated charcoal; In tetrahydrofuran; methanol;

DOI:10.1016/j.bmcl.2004.04.078

upstream raw materials:

tert-butyl 4-(1-hydroxy-2-nitroethyl)piperidine-1-carboxylate

tert butyl 4-formylpiperidine-1-carboxylate

rac-tert-butyl 4-[cyano(hydroxy)methyl]piperidine-1-carboxylate

tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

Downstream raw materials:

4-(1-hydroxy-2-phenylacetylamino-ethyl)-piperidine-1-carboxylic acid tert-butyl ester

tert-butyl 4-(2-{3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]benzoylamino}-1-hydroxyethyl)piperidine-1-carboxylate

tert-butyl 4-{2-[(2,4-dimethoxybenzyl)amino]-1-hydroxyethyl}piperidine-1-carboxylate

tert-butyl 4-{2-(2,4-dimethoxybenzyl)-1-oxo-7-[3-(trifluoromethoxy)phenyl]-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl}piperidine-1-carboxylate

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