benzyl O-[tert-butyl(dimethyl)silyl]-N-[4-(6-methoxypyridin-3-yl)phenyl]-N-(methylsulfonyl)homoserinate

Base Information

Chemical Name:benzyl O-[tert-butyl(dimethyl)silyl]-N-[4-(6-methoxypyridin-3-yl)phenyl]-N-(methylsulfonyl)homoserinate
CAS No.:1369963-11-0
Molecular Formula:C₃₀H₄₀N₂O₆SSi
Molecular Weight:584.809
Hs Code.:

Synonyms:benzyl O-[tert-butyl(dimethyl)silyl]-N-[4-(6-methoxypyridin-3-yl)phenyl]-N-(methylsulfonyl)homoserinate

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Chemical Property of benzyl O-[tert-butyl(dimethyl)silyl]-N-[4-(6-methoxypyridin-3-yl)phenyl]-N-(methylsulfonyl)homoserinate

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Technology Process of benzyl O-[tert-butyl(dimethyl)silyl]-N-[4-(6-methoxypyridin-3-yl)phenyl]-N-(methylsulfonyl)homoserinate

There total 6 articles about benzyl O-[tert-butyl(dimethyl)silyl]-N-[4-(6-methoxypyridin-3-yl)phenyl]-N-(methylsulfonyl)homoserinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1369963-10-9
benzyl N-(4-bromophenyl)-O-[tert-butyl(dimethyl)silyl]-N-(methylsulfonyl)homoserinate

: 163105-89-3,600726-67-8
2-methoxy-pyridine-5-boronic acid

: 1369963-11-0
benzyl O-[tert-butyl(dimethyl)silyl]-N-[4-(6-methoxypyridin-3-yl)phenyl]-N-(methylsulfonyl)homoserinate

Guidance literature:: With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 110 ℃; for 3h;

Reference yield:

: 106-40-1
4-bromo-aniline

: 1369963-11-0
benzyl O-[tert-butyl(dimethyl)silyl]-N-[4-(6-methoxypyridin-3-yl)phenyl]-N-(methylsulfonyl)homoserinate

Guidance literature:: Multi-step reaction with 6 steps

1: pyridine / dichloromethane / 1 h

2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.5 h / 0 °C

3: sodium hydroxide / methanol / 1 h / 20 °C

4: N,N-dimethyl-formamide / 0 - 20 °C

5: 1H-imidazole / N,N-dimethyl-formamide / 1 h / 20 °C

6: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 3 h / 110 °C

With pyridine; 1H-imidazole; di-isopropyl azodicarboxylate; potassium carbonate; triphenylphosphine; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 4284-50-8
N-(4-bromophenyl)methanesulfonamide

: 1369963-11-0
benzyl O-[tert-butyl(dimethyl)silyl]-N-[4-(6-methoxypyridin-3-yl)phenyl]-N-(methylsulfonyl)homoserinate

Guidance literature:: Multi-step reaction with 5 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.5 h / 0 °C

2: sodium hydroxide / methanol / 1 h / 20 °C

3: N,N-dimethyl-formamide / 0 - 20 °C

4: 1H-imidazole / N,N-dimethyl-formamide / 1 h / 20 °C

5: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 3 h / 110 °C

With 1H-imidazole; di-isopropyl azodicarboxylate; potassium carbonate; triphenylphosphine; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;