2-[6-({3-chloro-4-[(3-fluoro-benzyl)oxy]-phenyl}amino)-4,5-dihydro-2H-pyrimido[5',4':4,5]thieno[2,3-e]indazol-2-yl]ethanol

Base Information

• Chemical Name: 2-[6-({3-chloro-4-[(3-fluoro-benzyl)oxy]-phenyl}amino)-4,5-dihydro-2H-pyrimido[5',4':4,5]thieno[2,3-e]indazol-2-yl]ethanol
• CAS No.: 878014-28-9
• Molecular Formula: C₂₆H₂₁ClFN₅O₂S
• Molecular Weight: 522.002

Synonyms:2-[6-({3-chloro-4-[(3-fluoro-benzyl)oxy]-phenyl}amino)-4,5-dihydro-2H-pyrimido[5',4':4,5]thieno[2,3-e]indazol-2-yl]ethanol

Chemical Property of 2-[6-({3-chloro-4-[(3-fluoro-benzyl)oxy]-phenyl}amino)-4,5-dihydro-2H-pyrimido[5',4':4,5]thieno[2,3-e]indazol-2-yl]ethanol

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Technology Process of 2-[6-({3-chloro-4-[(3-fluoro-benzyl)oxy]-phenyl}amino)-4,5-dihydro-2H-pyrimido[5',4':4,5]thieno[2,3-e]indazol-2-yl]ethanol

There total 1 articles about 2-[6-({3-chloro-4-[(3-fluoro-benzyl)oxy]-phenyl}amino)-4,5-dihydro-2H-pyrimido[5',4':4,5]thieno[2,3-e]indazol-2-yl]ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)-N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-4,5-dihydro-2H-pyrimido[5',4':4,5]thieno[2,3-e]indazol-6-amine (878014-27-8) → 2-[6-({3-chloro-4-[(3-fluoro-benzyl)oxy]-phenyl}amino)-4,5-dihydro-2H-pyrimido[5',4':4,5]thieno[2,3-e]indazol-2-yl]ethanol (878014-28-9)

Guidance literature:

With hydrogenchloride; water; In tetrahydrofuran; at 0 - 20 ℃; for 4h; Product distribution / selectivity;

Reference yield: 93.0%

2-[6-({3-chloro-4-[(3-fluoro-benzyl)oxy]-phenyl}amino)-4,5-dihydro-2H-pyrimido[5',4':4,5]thieno[2,3-e]indazol-2-yl]ethanol (878014-28-9) + Methanesulfonic anhydride (7143-01-3) → 2-[6-({3-chloro-4-[(3-fluoro-benzyl)oxy]-phenyl}amino)-4,5-dihydro-2H-pyrimido[5',4':4,5]thieno[2,3-e]indazol-2-yl]ethylmethanesulfonate (878014-29-0)

Guidance literature:

With pyridine; In dichloromethane; at 0 - 20 ℃; for 6h; Product distribution / selectivity;

Reference yield:

2-[6-({3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}amino)-4,5-dihydro-3H-pyrimido[5',4':4,5]thieno[2,3-e]indazol-3-yl]ethanol (878014-52-9) + 2-[6-({3-chloro-4-[(3-fluoro-benzyl)oxy]-phenyl}amino)-4,5-dihydro-2H-pyrimido[5',4':4,5]thieno[2,3-e]indazol-2-yl]ethanol (878014-28-9) + Methanesulfonic anhydride (7143-01-3) → 2-[6-({3-chloro-4-[(3-fluoro-benzyl)oxy]-phenyl}amino)-4,5-dihydro-2H-pyrimido[5',4':4,5]thieno[2,3-e]indazol-2-yl]ethylmethanesulfonate (878014-29-0) + 2-[6-({3-chloro-4-[(3-fluoro-benzyl)oxy]-phenyl}amino)-4,5-dihydro-3H-pyrimido[5',4':4,5]thieno[2,3-e]indazol-3-yl]ethyl methanesulfonate

Guidance literature:

With pyridine; In dichloromethane; at 0 - 20 ℃; for 3h; Product distribution / selectivity;

upstream raw materials:

2-(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)-N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-4,5-dihydro-2H-pyrimido[5',4':4,5]thieno[2,3-e]indazol-6-amine

Downstream raw materials:

2-[6-({3-chloro-4-[(3-fluoro-benzyl)oxy]-phenyl}amino)-4,5-dihydro-2H-pyrimido[5',4':4,5]thieno[2,3-e]indazol-2-yl]ethylmethanesulfonate

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