Technology Process of 2-[4-(aminomethyl)-3-fluorophenyl]-N-[[5-tert-butyl-2-(3-chlorophenyl)-2H-pyrazol-3-yl]methyl]propionamide
There total 14 articles about 2-[4-(aminomethyl)-3-fluorophenyl]-N-[[5-tert-butyl-2-(3-chlorophenyl)-2H-pyrazol-3-yl]methyl]propionamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: hydrogenchloride; sodium nitrite / water / 0.5 h / 0 - 5 °C
1.2: 1 h / 75 °C
2.1: copper diacetate; pyridine / dichloromethane / 16 h / 23 °C
3.1: hydrogenchloride; palladium 10% on activated carbon; hydrogen / methanol / 6 h / 23 °C
4.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / 23 °C
5.1: nickel(II) chloride hexahydrate / ethanol / 0.25 h
5.2: 2 h
With
pyridine; hydrogenchloride; nickel(II) chloride hexahydrate; palladium 10% on activated carbon; hydrogen; copper diacetate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium nitrite;
In
methanol; ethanol; dichloromethane; water;
- Guidance literature:
-
C24H24ClFN4O;
With
nickel(II) chloride hexahydrate;
In
ethanol;
for 0.25h;
With
sodium tetrahydroborate; ethanol;
for 2h;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: 1.5 h / 0 - 23 °C
2.1: sodium hydride / paraffin oil; 1,4-dioxane / 0.75 h
2.2: 3 h / Reflux
3.1: hydrazine hydrate / ethanol / 3 h / Reflux
4.1: hydrogenchloride; sodium nitrite / water / 0.5 h / 0 - 5 °C
4.2: 1 h / 75 °C
5.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 23 °C
5.2: 0.5 h / 100 °C
6.1: hydrogenchloride; palladium 10% on activated carbon; hydrogen / methanol / 6 h / 23 °C
7.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / 23 °C
8.1: nickel(II) chloride hexahydrate / ethanol / 0.25 h
8.2: 2 h
With
hydrogenchloride; nickel(II) chloride hexahydrate; palladium 10% on activated carbon; hydrogen; sodium hydride; benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium nitrite;
In
1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide; paraffin oil;
