N-[[5-tert-butyl-2-(3-chlorophenyl)-2H-pyrazol-3-yl]methyl]-2-[3-fluoro-4-(methylaminomethyl)phenyl]propionamide

Base Information

Chemical Name:N-[[5-tert-butyl-2-(3-chlorophenyl)-2H-pyrazol-3-yl]methyl]-2-[3-fluoro-4-(methylaminomethyl)phenyl]propionamide
CAS No.:1402581-79-6
Molecular Formula:C₂₅H₃₀ClFN₄O
Molecular Weight:456.991
Hs Code.:

Synonyms:N-[[5-tert-butyl-2-(3-chlorophenyl)-2H-pyrazol-3-yl]methyl]-2-[3-fluoro-4-(methylaminomethyl)phenyl]propionamide

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Chemical Property of N-[[5-tert-butyl-2-(3-chlorophenyl)-2H-pyrazol-3-yl]methyl]-2-[3-fluoro-4-(methylaminomethyl)phenyl]propionamide

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Technology Process of N-[[5-tert-butyl-2-(3-chlorophenyl)-2H-pyrazol-3-yl]methyl]-2-[3-fluoro-4-(methylaminomethyl)phenyl]propionamide

There total 15 articles about N-[[5-tert-butyl-2-(3-chlorophenyl)-2H-pyrazol-3-yl]methyl]-2-[3-fluoro-4-(methylaminomethyl)phenyl]propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 82560-12-1,1237537-54-0
3-tert-butyl-1H-pyrazole-5-amine

: 1402581-79-6
N-[[5-tert-butyl-2-(3-chlorophenyl)-2H-pyrazol-3-yl]methyl]-2-[3-fluoro-4-(methylaminomethyl)phenyl]propionamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride; sodium nitrite / water / 0.5 h / 0 - 5 °C

1.2: 1 h / 75 °C

2.1: copper diacetate; pyridine / dichloromethane / 16 h / 23 °C

3.1: hydrogenchloride; palladium 10% on activated carbon; hydrogen / methanol / 6 h / 23 °C

4.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / 23 °C

5.1: nickel(II) chloride hexahydrate / ethanol / 0.25 h

5.2: 2 h

6.1: sodium methylate / methanol / 1.5 h / Reflux

6.2: 1 h / 0 °C / Reflux

With pyridine; hydrogenchloride; nickel(II) chloride hexahydrate; palladium 10% on activated carbon; hydrogen; sodium methylate; copper diacetate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium nitrite; In methanol; ethanol; dichloromethane; water;

Reference yield:

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1402583-57-6
2-[4-(aminomethyl)-3-fluorophenyl]-N-[[5-tert-butyl-2-(3-chlorophenyl)-2H-pyrazol-3-yl]methyl]propionamide

: 1402581-79-6
N-[[5-tert-butyl-2-(3-chlorophenyl)-2H-pyrazol-3-yl]methyl]-2-[3-fluoro-4-(methylaminomethyl)phenyl]propionamide

Guidance literature:: formaldehyd; 2-[4-(aminomethyl)-3-fluorophenyl]-N-[[5-tert-butyl-2-(3-chlorophenyl)-2H-pyrazol-3-yl]methyl]propionamide; With sodium methylate; In methanol; for 1.5h; Reflux;

With methanol; sodium tetrahydroborate; at 0 ℃; for 1h; Reflux;

Reference yield:

: 3282-30-2
pivaloyl chloride

: 1402581-79-6
N-[[5-tert-butyl-2-(3-chlorophenyl)-2H-pyrazol-3-yl]methyl]-2-[3-fluoro-4-(methylaminomethyl)phenyl]propionamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: 1.5 h / 0 - 23 °C

2.1: sodium hydride / paraffin oil; 1,4-dioxane / 0.75 h

2.2: 3 h / Reflux

3.1: hydrazine hydrate / ethanol / 3 h / Reflux

4.1: hydrogenchloride; sodium nitrite / water / 0.5 h / 0 - 5 °C

4.2: 1 h / 75 °C

5.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 23 °C

5.2: 0.5 h / 100 °C

6.1: hydrogenchloride; palladium 10% on activated carbon; hydrogen / methanol / 6 h / 23 °C

7.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / 23 °C

8.1: nickel(II) chloride hexahydrate / ethanol / 0.25 h

8.2: 2 h

9.1: sodium methylate / methanol / 1.5 h / Reflux

9.2: 1 h / 0 °C / Reflux

With hydrogenchloride; nickel(II) chloride hexahydrate; palladium 10% on activated carbon; hydrogen; sodium methylate; sodium hydride; benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium nitrite; In 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide; paraffin oil;