200801-92-9Relevant academic research and scientific papers
MODULATORS OF HCV REPLICATION
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Page/Page column 7, (2008/06/13)
The present invention is directed to the use of certain 2,4,5-trisubstituted imidazole derivatives in modulating the replication of Hepatitis C virus RNA and/or virus production in cells.
SUBSTITUTED IMIDAZOLES HAVING CYTOKINE INHIBITORY ACTIVITY
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Page/Page column 28, (2010/02/11)
Compounds represented by formula I: I are disclosed. AR represents an aromatic group containing 6-10 atoms; and represents a 4 to 10 membered non-aromatic heterocycle containing at least one N atom, and optionally containing 1-2 additional
Substituted imidazoles having cytokine inhibitory activity
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, (2008/06/13)
Compounds represented by formula I: STR1 are disclosed. AR represents an aromatic group containing 6-10 atoms; and STR2 represents a 4 to 10 membered non-aromatic heterocycle containing at least one N atom, and optionally containing 1-2 additio
Design and synthesis of potent, selective, and orally bioavailable tetrasubstituted imidazole inhibitors of p38 mitogen-activated protein kinase
Liverton, Nigel J.,Butcher, John W.,Claiborne, Christopher F.,Claremon, David A.,Libby, Brian E.,Nguyen, Kevin T.,Pitzenberger, Steven M.,Selnick, Harold G.,Smith, Garry R.,Tebben, Andrew,Vacca, Joseph P.,Varga, Sandor L.,Agarwal, Lily,Dancheck, Kim,Forsyth, Amy J.,Fletcher, Daniel S.,Frantz, Betsy,Hanlon, William A.,Harper, Coral F.,Hofsess, Scott J.,Kostura, Matthew,Lin, Jiunn,Luell, Sylvie,O'Neill, Edward A.,Orevillo, Chad J.,Pang, Margaret,Parsons, Janey,Rolando, Anna,Sahly, Yousif,Visco, Denise M.,O'Keefe, Stephen J.
, p. 2180 - 2190 (2007/10/03)
Novel potent and selective diarylimidazole inhibitors of p38 MAP (mitogen-activated protein) kinase are described which have activity in both cell-based assays of tumor necrosis factor-α (TNF-α) release and an animal model of rheumatoid arthritis. The SAR
