3-((tert-butyldimethylsilyl)oxy)propyl benzoate

Base Information

• Chemical Name: 3-((tert-butyldimethylsilyl)oxy)propyl benzoate
• CAS No.: 1056016-21-7
• Molecular Formula: C₁₆H₂₆O₃Si
• Molecular Weight: 294.466
• Mol file: 1056016-21-7.mol

Synonyms:3-((tert-butyldimethylsilyl)oxy)propyl benzoate

Chemical Property of 3-((tert-butyldimethylsilyl)oxy)propyl benzoate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-((tert-butyldimethylsilyl)oxy)propyl benzoate

There total 2 articles about 3-((tert-butyldimethylsilyl)oxy)propyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

3-tert-butyldimethylsilyloxy-1-propyl benzyl ether (203738-77-6) → 3-((tert-butyldimethylsilyl)oxy)propyl benzoate (1056016-21-7)

Guidance literature:

With air; eosin Y-sensitized titanium dioxide; In acetone; at 20 ℃; for 12h;

DOI:10.1021/acscatal.7b03029

Reference yield: 73.0%

1-benzoylimidazole (10364-94-0) + 3-tert-butyldimethylsilyloxy-1-propanol (73842-99-6) → 3-((tert-butyldimethylsilyl)oxy)propyl benzoate (1056016-21-7)

Guidance literature:

With pyridine hydrochloride; In acetonitrile; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1021/ol300339q

Reference yield: 94.0%

3-((tert-butyldimethylsilyl)oxy)propyl benzoate (1056016-21-7) → 3-hydroxypropyl benzoate (6946-99-2)

Guidance literature:

With pyridinium hydrobromide perbromide; In methanol; at -20 ℃; for 1.5h;

DOI:10.1016/j.tetlet.2008.06.072

upstream raw materials:

1-benzoylimidazole

3-tert-butyldimethylsilyloxy-1-propanol

3-tert-butyldimethylsilyloxy-1-propyl benzyl ether

Downstream raw materials:

3-hydroxypropyl benzoate

Refernces

• 1、 Heller, Stephen T.,Fu, Tingting,Sarpong, Richmond. "Dual Bronsted acid/nucleophilic activation of carbonylimidazole derivatives". supporting information; experimental part. p. 1970 - 1973. Retrieved 2012/06/01.