N-(azetidin-1-ylsulfonyl)-5-chloro-4-{[(5-chloro-6-cyclopropylpyridin-3-yl)oxy]methyl}-2-fluorobenzamide

Base Information

Chemical Name:N-(azetidin-1-ylsulfonyl)-5-chloro-4-{[(5-chloro-6-cyclopropylpyridin-3-yl)oxy]methyl}-2-fluorobenzamide
CAS No.:1443431-33-1
Molecular Formula:C₁₉H₁₈Cl₂FN₃O₄S
Molecular Weight:474.34
Hs Code.:

Synonyms:N-(azetidin-1-ylsulfonyl)-5-chloro-4-{[(5-chloro-6-cyclopropylpyridin-3-yl)oxy]methyl}-2-fluorobenzamide

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Chemical Property of N-(azetidin-1-ylsulfonyl)-5-chloro-4-{[(5-chloro-6-cyclopropylpyridin-3-yl)oxy]methyl}-2-fluorobenzamide

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Technology Process of N-(azetidin-1-ylsulfonyl)-5-chloro-4-{[(5-chloro-6-cyclopropylpyridin-3-yl)oxy]methyl}-2-fluorobenzamide

There total 5 articles about N-(azetidin-1-ylsulfonyl)-5-chloro-4-{[(5-chloro-6-cyclopropylpyridin-3-yl)oxy]methyl}-2-fluorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 654073-32-2
1-azetidine-1-sulfonamide

: 1443431-27-3
5-chloro-4-(((5-chloro-6-cyclopropylpyridin-3-yl)oxy)methyl)-2-fluorobenzoic acid

: 1443431-33-1
N-(azetidin-1-ylsulfonyl)-5-chloro-4-{[(5-chloro-6-cyclopropylpyridin-3-yl)oxy]methyl}-2-fluorobenzamide

Guidance literature:: 5-chloro-4-(((5-chloro-6-cyclopropylpyridin-3-yl)oxy)methyl)-2-fluorobenzoic acid; With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; for 0.25h;

1-azetidine-1-sulfonamide; at 20 ℃; for 18h;

Reference yield:

: 1263274-67-4
5-chloro-2-fluoro-4-methylbenzoic acid

: 1443431-33-1
N-(azetidin-1-ylsulfonyl)-5-chloro-4-{[(5-chloro-6-cyclopropylpyridin-3-yl)oxy]methyl}-2-fluorobenzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: dmap / tert-butyl alcohol / 18 h / 45 °C / Inert atmosphere

2.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 85 °C / Inert atmosphere

3.1: potassium carbonate / dimethyl sulfoxide / 18 h / 20 °C / Inert atmosphere

4.1: trifluoroacetic acid / dichloromethane / 20 °C / Inert atmosphere

5.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 0.25 h

5.2: 18 h / 20 °C

With dmap; N-Bromosuccinimide; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; dibenzoyl peroxide; In tetrachloromethane; dichloromethane; dimethyl sulfoxide; tert-butyl alcohol;

Reference yield:

: 1443432-84-5
tert-butyl 5-chloro-4-(((5-chloro-6-cyclopropylpyridin-3-yl)oxy)methyl)-2-fluorobenzoate

: 1443431-33-1
N-(azetidin-1-ylsulfonyl)-5-chloro-4-{[(5-chloro-6-cyclopropylpyridin-3-yl)oxy]methyl}-2-fluorobenzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 20 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 0.25 h

2.2: 18 h / 20 °C

With N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In dichloromethane;