5-chloro-4-(((5-chloro-6-cyclopropylpyridin-3-yl)oxy)methyl)-2-fluorobenzoic acid

Base Information

• Chemical Name: 5-chloro-4-(((5-chloro-6-cyclopropylpyridin-3-yl)oxy)methyl)-2-fluorobenzoic acid
• CAS No.: 1443431-27-3
• Molecular Formula: C₁₆H₁₂Cl₂FNO₃
• Molecular Weight: 356.181
• Mol file: 1443431-27-3.mol

Synonyms:5-chloro-4-(((5-chloro-6-cyclopropylpyridin-3-yl)oxy)methyl)-2-fluorobenzoic acid

Chemical Property of 5-chloro-4-(((5-chloro-6-cyclopropylpyridin-3-yl)oxy)methyl)-2-fluorobenzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-chloro-4-(((5-chloro-6-cyclopropylpyridin-3-yl)oxy)methyl)-2-fluorobenzoic acid

There total 4 articles about 5-chloro-4-(((5-chloro-6-cyclopropylpyridin-3-yl)oxy)methyl)-2-fluorobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 5-chloro-4-(((5-chloro-6-cyclopropylpyridin-3-yl)oxy)methyl)-2-fluorobenzoate (1443432-84-5) → 5-chloro-4-(((5-chloro-6-cyclopropylpyridin-3-yl)oxy)methyl)-2-fluorobenzoic acid (1443431-27-3)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; Inert atmosphere;

Reference yield:

5-chloro-2-fluoro-4-methylbenzoic acid (1263274-67-4) → 5-chloro-4-(((5-chloro-6-cyclopropylpyridin-3-yl)oxy)methyl)-2-fluorobenzoic acid (1443431-27-3)

Guidance literature:

Multi-step reaction with 4 steps

1: dmap / tert-butyl alcohol / 18 h / 45 °C / Inert atmosphere

2: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 85 °C / Inert atmosphere

3: potassium carbonate / dimethyl sulfoxide / 18 h / 20 °C / Inert atmosphere

4: trifluoroacetic acid / dichloromethane / 20 °C / Inert atmosphere

With dmap; N-Bromosuccinimide; potassium carbonate; trifluoroacetic acid; dibenzoyl peroxide; In tetrachloromethane; dichloromethane; dimethyl sulfoxide; tert-butyl alcohol;

Reference yield:

tert-butyl 5-chloro-2-fluoro-4-methylbenzoate (1443432-75-4) → 5-chloro-4-(((5-chloro-6-cyclopropylpyridin-3-yl)oxy)methyl)-2-fluorobenzoic acid (1443431-27-3)

Guidance literature:

Multi-step reaction with 3 steps

1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 85 °C / Inert atmosphere

2: potassium carbonate / dimethyl sulfoxide / 18 h / 20 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 20 °C / Inert atmosphere

With N-Bromosuccinimide; potassium carbonate; trifluoroacetic acid; dibenzoyl peroxide; In tetrachloromethane; dichloromethane; dimethyl sulfoxide;

upstream raw materials:

tert-butyl 5-chloro-2-fluoro-4-methylbenzoate

5-chloro-2-fluoro-4-methylbenzoic acid

tert-butyl 5-chloro-4-(((5-chloro-6-cyclopropylpyridin-3-yl)oxy)methyl)-2-fluorobenzoate

tert-butyl 5-chloro-4-(bromomethyl)-2-fluorobenzoate

Downstream raw materials:

5-chloro-4-{[(5-chloro-6-cyclopropylpyridin-3-yl)oxy]methyl}-N[(dimethylamino)sulfonyl]-2-fluorobenzamide diethylamine salt

N-(azetidin-1-ylsulfonyl)-5-chloro-4-{[(5-chloro-6-cyclopropylpyridin-3-yl)oxy]methyl}-2-fluorobenzamide

5-chloro-4-{[(5-chloro-6-cyclopropylpyridin-3-yl)oxy]methyl}-N-[(3,3-difluoroazetidin-1-yl)sulfonyl]-2-fluorobenzamide