tert-butyl 5-chloro-4-(((5-chloro-6-cyclopropylpyridin-3-yl)oxy)methyl)-2-fluorobenzoate

Base Information

• Chemical Name: tert-butyl 5-chloro-4-(((5-chloro-6-cyclopropylpyridin-3-yl)oxy)methyl)-2-fluorobenzoate
• CAS No.: 1443432-84-5
• Molecular Formula: C₂₀H₂₀Cl₂FNO₃
• Molecular Weight: 412.288
• Mol file: 1443432-84-5.mol

Synonyms:tert-butyl 5-chloro-4-(((5-chloro-6-cyclopropylpyridin-3-yl)oxy)methyl)-2-fluorobenzoate

Chemical Property of tert-butyl 5-chloro-4-(((5-chloro-6-cyclopropylpyridin-3-yl)oxy)methyl)-2-fluorobenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 5-chloro-4-(((5-chloro-6-cyclopropylpyridin-3-yl)oxy)methyl)-2-fluorobenzoate

There total 3 articles about tert-butyl 5-chloro-4-(((5-chloro-6-cyclopropylpyridin-3-yl)oxy)methyl)-2-fluorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

5-chloro-6-cyclopropylpyridin-3-ol (1355067-18-3) + tert-butyl 5-chloro-4-(bromomethyl)-2-fluorobenzoate (1443432-77-6) → tert-butyl 5-chloro-4-(((5-chloro-6-cyclopropylpyridin-3-yl)oxy)methyl)-2-fluorobenzoate (1443432-84-5)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 20 ℃; for 18h; Inert atmosphere;

Reference yield:

5-chloro-2-fluoro-4-methylbenzoic acid (1263274-67-4) → tert-butyl 5-chloro-4-(((5-chloro-6-cyclopropylpyridin-3-yl)oxy)methyl)-2-fluorobenzoate (1443432-84-5)

Guidance literature:

Multi-step reaction with 3 steps

1: dmap / tert-butyl alcohol / 18 h / 45 °C / Inert atmosphere

2: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 85 °C / Inert atmosphere

3: potassium carbonate / dimethyl sulfoxide / 18 h / 20 °C / Inert atmosphere

With dmap; N-Bromosuccinimide; potassium carbonate; dibenzoyl peroxide; In tetrachloromethane; dimethyl sulfoxide; tert-butyl alcohol;

Reference yield:

tert-butyl 5-chloro-2-fluoro-4-methylbenzoate (1443432-75-4) → tert-butyl 5-chloro-4-(((5-chloro-6-cyclopropylpyridin-3-yl)oxy)methyl)-2-fluorobenzoate (1443432-84-5)

Guidance literature:

Multi-step reaction with 2 steps

1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 85 °C / Inert atmosphere

2: potassium carbonate / dimethyl sulfoxide / 18 h / 20 °C / Inert atmosphere

With N-Bromosuccinimide; potassium carbonate; dibenzoyl peroxide; In tetrachloromethane; dimethyl sulfoxide;

upstream raw materials:

tert-butyl 5-chloro-2-fluoro-4-methylbenzoate

5-chloro-2-fluoro-4-methylbenzoic acid

5-chloro-6-cyclopropylpyridin-3-ol

tert-butyl 5-chloro-4-(bromomethyl)-2-fluorobenzoate

Downstream raw materials:

5-chloro-4-(((5-chloro-6-cyclopropylpyridin-3-yl)oxy)methyl)-2-fluorobenzoic acid

5-chloro-4-{[(5-chloro-6-cyclopropylpyridin-3-yl)oxy]methyl}-N[(dimethylamino)sulfonyl]-2-fluorobenzamide diethylamine salt

N-(azetidin-1-ylsulfonyl)-5-chloro-4-{[(5-chloro-6-cyclopropylpyridin-3-yl)oxy]methyl}-2-fluorobenzamide

5-chloro-4-{[(5-chloro-6-cyclopropylpyridin-3-yl)oxy]methyl}-N-[(3,3-difluoroazetidin-1-yl)sulfonyl]-2-fluorobenzamide